No molecular biomarkers have been proven applicable in clinical practice to identify patients who can benefit from adjuvant chemotherapy non-small cell lung cancer (NSCLC). In this study, we established a biomarker, RPMB, short for promotor methylation burden of DNA repair genes (DRGs), the subgroup might NSCLC. Methylation profiles 828 NSCLC primary tumors and their information were downloaded...

We study model predictions for the abundance and clustering of high-redshift galaxies, and for the properties of their descendants. We focus on three high-redshift populations: Lyman break galaxies at z ∼ 3 (LBGs), optically selected star-forming galaxies at z ∼ 2 (BXs), and distant red galaxies at z ∼ 2 (DRGs). We select model galaxies from mock catalogues using the observationally defined col...

Spontaneous pain, a poorly understood aspect of human neuropathic pain, is indicated in animals by spontaneous foot lifting (SFL). To determine whether SFL is caused by spontaneous firing in nociceptive neurons, we studied the following groups of rats: (1) untreated; (2) spinal nerve axotomy (SNA), L5 SNA 1 week earlier; (3) mSNA (modified SNA), SNA plus loose ligation of the adjacent L4 spinal...

Objectives The aim of this article is to study patient satisfaction with complementary and alternative medicine (CAM) in an in-hospital setting before and after the introduction of diagnosis-related groups (DRGs). Methods Patients were interviewed regarding a general evaluation of their hospital stay, the psychological talking therapy, the nutrition therapy, and the overall success of the tre...

The Hospital Inpatient Enquiry (HIPE) system is currently used as a principle source of national data on discharges from acute hospitals. The Casemix Programme is used to calculate funding for patient care (HIPE activity and Specialty Costs Returns). Th coding is usually undertaken by clerical personnel. We were concerned that the medical complexity of our stroke patients was not captured by th...

The primary objective of this article is to explore the feasibility of the application of cost minimization analysis in a teaching hospital environment. The investigation is concerned with the development of cost per admission and cost per patient day models. These models are further used for determining the value of the length of stay that would minimize cost per patient day (projected length ...

Very deep near-infrared observations in the Faint InfraRed Extragalactic Survey (FIRES) have recently uncovered a significant population of red galaxies at redshifts z > 2. These distant red galaxies (DRGs) are efficiently selected by the criterion Js−Ks > 2.3. We use Chandra data to examine the X-ray emission from DRGs in the 5×5 FIRES MS 1054–03 field. Two of 40 DRGs with Ks < 22 are detected...

Despite the benefits of studying multiple patient outcomes together, research on between-hospital variation has often focused single or disease-specific study populations. In this we examined nationwide temporal trends and in in-hospital mortality, 30-day readmissions length-of-stay above All-Patient-Refined Diagnoses-Related-Group (APR-DRG)-specific 90th percentile (pLOS). We modelled 13,660,1...

BACKGROUND Secretagogin (Scgn), a member of the EF-hand calcium-binding protein (CaBP) superfamily, has recently been found in subsets of developing and adult neurons. Here, we have analyzed the expression of Scgn in dorsal root ganglia (DRGs) and trigeminal ganglia (TGs), and in spinal cord of mouse at the mRNA and protein levels, and in comparison to the well-known CaBPs, calbindin D-28k, par...