The objective of the present investigation is to formulate Nizatidine loaded superporous floating hydrogel tablets. In the present study Nizatidine floating tablets were prepared by effervescence method using sodium bicarbonate as a gas generating agent. The tablets were formulated using direct compression technology by employing polymers like chitosan, carbopol 934p and ethyl cellulose. The pr...

Floating matrix tablets of domperidone were developed to prolong gastric residence time and thereby increased drug bioavailability. Domperidone was chosen as a model drug because it is poorly absorbed from the lower gastrointestinal tract. The tablets were prepared by wet granulation technique, using polymers such as hydroxypropylmethylcellulose K4M, carbopol 934P, and sodium alginate, either a...

objective eudragits are widely used polymers in the production of oral sustained release dosage forms. the application of these polymers in the production of inert insoluble matrices has been investigated. however the effect of particle size, compaction force and presence of aerosil 200 as a glidant on the properties of eudragit rs and rl matrices prepared by direct compression of their physica...

Incorporation of bisphosphonates in the lipid reduces gastric irritation. Only gastric retention with sustained release allows the drug to reach the duodenum and jejunum and improves the availability of bisphosphonates. Risedronate sodium and Gelucire 39/01 floating matrices were prepared using melt solidification. The sustained release floating matrices were evaluated for in vitro and in vivo ...

starch could used as ingredient fillers, binders and crushers in tablet manufacture. Amylum is also defined carbohydrates from plant, results photosynthesis, which stored part certain plant backup food mixture two type structure different polysaccharides that contains (17-20) % amylose (80-83) amylopectin. Destination study this for know the formulation of mucoadhesive tablets with fully gelati...

Over the past 30 years as the expense and complications involved in marketing new drug entities have increased, with concomitant recognition of the therapeutic advantages of controlled drug delivery, greater attention has been focused on development of sustained or controlled release drug delivery systems. Bilayer tablet is new era for the successful development of controlled release formulatio...

PURPOSE The aim of the present study was to improve the bioavailability of itopride (ITO) and sustain its action by formulating as a floating dosage form. MATERIALS AND METHODS Sustained-release floating tablets of ITO hydrochloride (HCl) were prepared by direct compression using different hydrocolloid polymers such as hydroxypropyl methylcellulose and ethylcellulose and/or methacrylic acid p...

Metformin hydrochloride (metformin HCl) was formulated as a hydrophobic matrix sustained release tablet employing wax materials and the sustained release behavior of the fabricated tablet was investigated. Sustained release matrix tablets containing 500 mg metformin HCl were developed using different bees wax combinations. The tablets were prepared by wet granulation technique. The formulation ...

The aim of the study was to evaluate the effect of systematic agitation, increasing ionic strength and gel strength on drug release from a gel-forming matrix (HPMC E10M, E4M and E50LV) using USP type III Bio-Dis apparatus with theophylline as a model drug. The triboelectric charging; particle sizing, water content, true density and SEM of all the hypromellose grades, theophylline and formulated...

The rapid release from a double-compressed tablet containing theophylline with the water-soluble polymer, hydroxypropylmethylcellulose (HPMC) or hydroxypropylmethylcellulose phthalate (HPMCP), used as a wall material can be suppressed by argon plasma-irradiation and changed into the sustained-release system due to a decrease in solubility of the outer layer. It was shown that the release profil...