481 Fom the point of view of oligodendrocyte and demyelinated axon interaction, glial scars of reactive astrocytes obstruct to myelinating oligodendrocytes the access to naked axons. On the other hand, astrocytes also produce neurotrophic factors that promote remyelination. An alternative strategy that CNS cells have to avoid axonal damage, when remyelination is not efficient, consists in that ...

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objective: multiple sclerosis (ms) is an immune-mediated demyelinating disease of the central nervous system (cns). stem cell transplantation is a new therapeutic approach for demyelinating diseases such as ms which may promote remyelination. in this study, we evaluate the remyelinating potential of adipose mesenchymal stem cells (adscs) and their effect on neural cell composition in the corpus...

multiple sclerosis is an autoimmune cns-disease characterized by inflammatory neurodegenerative events occurring with de- and remyelination. recent evidence show that demyelinated neurons are less excitable than myelinated ones while at early stages of remyelination these neurons seem to be hyperexcitable. the latter is a transitory condition that, very likely, leads to impaired neuronal networ...

previous studies have demonstrated the potential of monotherapy with either mesenchymal stem cells (mscs) or estrogen in autoimmune and cuprizone models of multiple sclerosis (ms). the aim of this study was to examine the effects of co-administration of 17β-estradiol (e2) and adipose-derived mesenchymal stem cells (adscs) on remyelination of corpus callosum axons in a cuprizone model of ms. for...