Renal injury can occur during sports activity. Although it is, generally, associated with contact trauma, it is known that the renal injury can be developed during training without a direct trauma. The diagnosis of renal injuries should not be based solely on urine analysis. Computed tomography scan is necessary diagnose possible renal injuries.

The assessment of biomarkers to detect renal injury has been studied before, but the sensitivity and specificity of urinary and serum profiles of these markers still need to be improved. One of the promising new markers for detection of renal injury is the family of 15 kDa cytoplasmic fatty acid-binding proteins (FABPs). Remarkably, however, the application of FABP as marker for renal injury du...

INTRODUCTION Mechanical ventilation (MV) can injure the lungs and contribute to an overwhelming inflammatory response, leading to acute renal failure (ARF). We previously showed that poly(adenosine diphosphate-ribose) polymerase (PARP) is involved in the development of ventilator-induced lung injury (VILI) and the related ARF, but the mechanisms underneath remain unclear. In the current study w...

BACKGROUND AND OBJECTIVES Renal histological injury patterns in type 2 diabetes are heterogeneous. We compared renal histological injury patterns using renal biopsy findings with renal function and followed up renal functional changes in normoalbuminuric and microalbuminuric patients with type 2 diabetes to determine whether renal function progresses according to injury patterns. DESIGN SETTI...

Background: Corn silk (CS) is widely used in Iranian traditional medicine and Feijoa sellowiana(FS) is a native plant widespread in the Southern parts of Iran. The aim of the present study was to assess renal protective activities of CS and FS against dosage induced injury by ecstasy (MDMA) using insitu rat renal perfusion (IRRP) system.Methods: Hydro-alcoholic extract of CS and FS (10, 20, 40 ...

Neonatal Acute Kidney Injury (AKI) is characterized by a sudden decline in renal function, or failure of physiologic rise glomerular filtrate rate, leading to the kidneys' inability maintain fluid and electrolyte homeostasis.1,2 Despite significant attention given epidemiology acute kidney injury adult older paediatric populations, there paucity data on neonatal AKI. There has been notable lack...

Tissue fibrosis and chronic inflammation are common causes of progressive organ damage, including progressive renal disease, leading to loss of physiological functions. Recently, it was shown that Toll-like receptor 2 (TLR2) is expressed in the kidney and activated by endogenous danger signals. The expression and function of TLR2 during renal fibrosis and chronic inflammation has however not ye...

BACKGROUND/AIMS Parstatin is a 41-mer peptide formed by proteolytic cleavage on activation of the protease-activated receptor 1. Parstatin was recently found to be cardioprotective against myocardial ischemia/reperfusion (IR) injury. In the present study, it was hypothesized that parstatin would protect the kidneys in acute renal failure. METHODS We investigated the effects of parstatin on th...

The role of renal microvascular endothelial cell injury in the pathophysiology of ischemic acute renal failure (ARF) remains largely unknown. No consistent morphological alterations have been ascribed to the endothelium of the renal microvasculature as a result of ischemia-reperfusion injury. Therefore, the purpose of this study was to examine biochemical markers of endothelial injury and morph...

The volatile anesthetic isoflurane protects against renal ischemia and reperfusion injury by releasing renal tubular TGF-β1. As adenosine is a powerful cytoprotective molecule, we tested whether TGF-β1 generated by isoflurane induces renal tubular ecto-5'-nucleotidase (CD73) and adenosine to protect against renal ischemia and reperfusion injury. Isoflurane induced new CD73 synthesis and increas...