All the world's religions recommend a period of fasting, and of these, one whole month of intermittent fasting every year is particular to Islam. Muslims have two meals, one immediately after sunset and the other just before dawn with a period of fasting ranging from 11-18 hours. Therefore, we can assume that physiological changes occurring during Ramadan would be different from those occurring...

Michel Baum, Katherine Twombley, Jyothsna Gattineni, Catherine Joseph, Lin Wang, Qiuyu Zhang, Vangipuram Dwarakanath, and Orson W. Moe Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas; Dallas, Texas; Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas; Dallas, Texas; Department of Physiology, University of Texas Southwest...

Renal proximal tubules secrete various organic anions, including drugs and p-aminohippurate (PAH). Uptake of PAH from blood into tubule cells occurs by exchange with intracellular alpha-ketoglutarate and is mediated by the organic anion transporter 1. PAH exit into tubule lumen is species specific and may involve ATP-independent and -dependent transporters.

FIRST OF ALL, I WOULD LIKE TO THANK Tom Kleyman for his service as Editor-in-Chief of AJP-Renal Physiology for the last six years. Tom has shown exemplary leadership during his tenure, and the journal has grown and increased in recognition as one of the leaders in publishing outstanding renal research. Also, I would like to thank my fellow Associate Editors, Gerry Apodaca, Jeff Garvin, Lisa Sta...

Recent advances in molecular biology have identified three organic anion transporter families: the organic anion transporter (OAT) family encoded by SLC22A, the organic anion transporting peptide (OATP) family encoded by SLC21A (SLCO), and the multidrug resistance-associated protein (MRP) family encoded by ABCC. These families play critical roles in the transepithelial transport of organic anio...

Research in resistant hypertension has again focused on autonomic nervous system denervation - 50 years after it had been stopped due to postural hypotension and availability of newer drugs. These (ganglionic blockers) drugs have all been similarly stopped, due to postural hypotension and yet newer antihypertensive agents. Recent demonstration of the feasibility of limited regional transcathete...

This manuscript discusses current concepts of glomerular filtration and tubular transport of sodium, water, potassium, and urinary acidification by vertebrate kidneys in a comparative context. Work in mammalian and amphibian nephrons receives major emphasis due to our interest in application of new techniques for investigation of cellular mechanisms; when available, data from other vertebrate c...

Potassium is the most abundant cation in the intracellular fluid, and maintaining the proper distribution of potassium across the cell membrane is critical for normal cell function. Long-term maintenance of potassium homeostasis is achieved by alterations in renal excretion of potassium in response to variations in intake. Understanding the mechanism and regulatory influences governing the inte...