Introduction Pharmacokinetic (PK) of drugs in critically ill patients could vary from the general population. The pharmacokinetics of linezolid presents a high variability. Patients undergoing renal replacement therapy (RRT) could present lower linezolid concentration than expected. The pharmacokinetic/pharmacodynamic analysis (PK/ PD) is a useful tool to optimize dosing regimens of antibiotic ...

BACKGROUND Renal failure with following continuous renal replacement therapy is a major clinical problem in liver transplant recipients, with reported incidences of 3% to 20%. Little is known about the significance of postoperative acute renal failure or acute-on-chronic renal failure to postoperative outcome in liver transplant recipients. METHODS In this post hoc analysis we compared the mo...

Often, too little consideration is given to the fluids used in all forms of continuous renal replacement therapy (CRRT). However, errors in fluid prescription, delivery, or creation can be rapidly fatal; in addition, fluid associated expenses can be the overriding cost in continuous renal replacement therapies. While a standard solution is frequently acceptable in most clinical circumstances, s...

Abstract Approximately 340,000 people in Japan are on chronic dialysis, and this number continues to increase. Even today, hemodialysis is the most frequently selected modality for renal replacement therapy Japan, accounting approximately 97% of dialysis patients. This because facilities insurance were developed early results treatment very good. Most cases kidney disease associated with diabet...

Renal dysfunction in the setting of heart failure is a common medical problem. This dysfunction can range from reversible ischemic changes to renal failure requiring renal replacement therapy. Patients who are candidates for mechanical circulatory support with left ventricular assistant device (LVAD) pose unique challenge with respect to receiving dialysis. We present a 47 year old patient who ...

BACKGROUND The optimal intensity of renal-replacement therapy in critically ill patients with acute kidney injury is controversial. METHODS We randomly assigned critically ill patients with acute kidney injury and failure of at least one nonrenal organ or sepsis to receive intensive or less intensive renal-replacement therapy. The primary end point was death from any cause by day 60. In both ...

Acute renal failure in critically ill patients is a growing clinical problem. Options for renal replacement therapy in these patients use convective and diffusive clearance and may be intermittent, as in classic hemodialysis, or continuous. New ways of delivering dialysis in the intensive care unit, such as sustained low-efficiency dialysis, are also under development. It may be that renal repl...

Acute renal failure (ARF) requiring dialysis is a common complication of patients in intensive care unit (ICU). Dialysis can be performed with either intermittent hemodialysis (IHD) or continuous renal replacement therapy (CRRT). CRRT is associated with less hemodynamic instability. Therefore, it is preferred in critically ill and hypotensive patients in ICU. However, current evidence does not ...