Kidney transplant recipients (KTR) have a higher risk of developing malignancies compared to the general population, due immunosuppressive regimens which can promote oncogenesis process. The incidence de novo non-melanoma skin cancer (NMSC) in KTR is greater than population. Basal cell carcinoma (BCC) represents one most frequent KTR. Sonidegib Hedgehog signaling pathway inhibitor approved for ...

Human herpesvirus 8 (HHV8) is a herpesvirus that is always associated with Kaposi sarcoma. An enzyme-linked immunoenzymatic assay was used to detect antibodies to the latent nuclear antigen of HHV8 in kidney transplant patients and kidney transplant candidates from Tunisia. A significantly high HHV8 seroprevalence was documented; 17% of kidney transplant patients and 23% in kidney transplant ca...

The major histocompatibility complex (MHC) class I chain-related gene A (MICA) is located centromerically to the human leukocyte antigen (HLA)-B. The short distance between these loci in the MHC indicates the presence of linkage disequilibrium (LD). Similarly to the HLA, the MICA is highly polymorphic, and this polymorphism has not been well documented in different populations. In this study, w...

INTRODUCTION Indigenous Australians suffer markedly higher rates of end-stage kidney disease (ESKD) but are less likely than their non-Indigenous counterparts to receive a transplant. This difference is not fully explained by measurable clinical differences. Previous work suggests that Indigenous Australian patients may be regarded by treating specialists as 'non-compliers', which may negativel...

heart failure is common in patients with chronic renal disease, either as a complication of renal failure or from shared risk factors, or is the major cause of death in patients on dialysis. at present, end stage renal disease (esrd) patients who have systolic heart failure are considered high-risk for surgery; and nephrologists and cardiologists are reluctant to refer these patients for kidney...

BACKGROUND Kidney transplant candidates undergo rigorous testing prior to clearance for transplantation. Because kidney transplant candidates may be at increased risk for carotid artery stenosis because of arteriosclerosis and atherosclerosis secondary to hypertension, vascular calcification, and diabetes, carotid ultrasound is often performed with the intent of preventing a cerebrovascular acc...

introduction: mycobacterial tuberculosis (tb) infection is a serious opportunistic infection in renal transplant patients. although tb is normally considered as an opportunistic infection of the early period, it can be diagnosed at any time. in this study four patients who suffered from tb were examined. cases report: among 200 patients who were monthly examined in sina hospital of tehran, tb w...

A cquired cystic kidney disease (ACKD) may have been first described more than a century ago (1). Its recognition as a disease of consequence in patients who undergo long-term maintenance hemodialysis was in the 1970s (2). In the ensuing three decades, repeated cross-sectional studies have corroborated early findings that this disease affects one third or more of long-term ( 3 yr) hemodialysis ...

Infections are a significant cause of morbidity in the form graft loss and mortality Renal Transplant Recipients (RTR). Several factors pre peri-transplant period increase susceptibility to Post (PTI), affecting overall patient survival.