Aging is characterized by a stochastic accumulation of molecular damage, progressive failure of maintenance and repair, and consequent onset of age-related diseases. Applying hormesis in aging research and therapy is based on the principle of stimulation of maintenance and repair pathways by repeated exposure to mild stress. In a series of experimental studies we have shown that repetitive mild...

Nowadays, multiple constraints imposed by economical, social and environmental considerations undergo maintenance planning optimization into a major challenge to designers, owners and users of infrastructure. This study presents a simplified methodology to evaluate the sustainability of maintenance strategies used in reinforced concrete structures exposed to chlorides. The proposed approach is ...

This paper presents an original software tool based on a model of expert system that has been developed to satisfy the requirements of fault diagnosis, repair and maintenance of electrical machines in industrial, educational or other applications. This software comprises an SQL server database and provides different user levels (simple user, power user and administrator). By the introduction of...

This paper considers a k-out-of-N system with identical, repairable components. Maintenance is initiated when the number of failed components exceeds some critical level. After a possible set-up time, all failed components are replaced by spares. A multi-server repair shop repairs the failed components. The system availability depends on the spare part stock level, the maintenance policy and th...

The genome of the model plant Arabidopsis thaliana encodes many orthologs of human genome-maintenance proteins, and in several important cases plant DNA repair and mutation-antagonism functions resemble their mammalian counterparts more closely than do those of established microbial models. These orthologs, in conjunction with the powerful tools now available for work with Arabidopsis and the p...

We address the problem of minimal-change integrity maintenance in the context of integrity constraints in relational databases. We assume that integrity-restoration actions are limited to tuple deletions. We identify two basic computational issues: repair checking (is a database instance a repair of a given database?) and consistent query answers [ABC99] (is a tuple an answer to a given query i...

We address the problem of minimal-change integrity maintenance in the context of integrity constraints in relational databases. Using the framework proposed by Arenas, Bertossi, and Chomicki [4], we focus on two basic computational issues: repair checking (is a database instance a repair of a given database?) and consistent query answers (is a tuple an answer to a given query in every repair of...

DNA double strand breaks (DSBs) are repaired by an extensive network of proteins that recognize damaged DNA and catalyze its repair. By virtue of their similarity, the normal ends of linear chromosomes and internal DNA DSBs are both potential substrates for DSB repair enzymes. Thus, telomeres, specialized nucleo-protein complexes that cap chromosomal ends, serve a critical function to different...

An optimal scheme of road paving maintenance was investigated by examining the environmental loading and cost considerations of pavement operations over a 30-year life cycle. Results indicated that the application of recycled materials in pavement construction and repair reduced the effects of environmental loading over the life cycle by approximately 40%. Furthermore, it was observed that envi...