BACKGROUND Measuring progression of Parkinson disease (PD) using positron emission tomography may help demonstrate the efficacy of neuroprotective treatments. To date, (18)F-dopa has been the gold standard to measure presynaptic dopaminergic function in PD, but this tracer might overestimate the rate of neuronal death in PD because its uptake also depends on dopamine turnover rather than exclus...

BACKGROUND AND PURPOSE We studied the influence of reperfusion on carrier and barrier functions of the blood-brain barrier after transient global ischemia in rats. METHODS We used iodine-125-labeled 3-iodo-alpha-methyl-L-tyrosine and carbon-14-labeled sucrose as tracers for studying carrier and barrier functions of the blood-brain barrier, respectively. Brain uptakes of these two tracers were...

Background and Purpose: We studied the influence of reperfusion on carrier and barrier functions of the blood-brain barrier after transient global ischemia in rats. Methods: We used iodine-125-labeled 3-iodo-a-methyl-L-tyrosine and carbon-14-labeled sucrose as tracers for studying carrier and barrier functions of the blood-brain barrier, respectively. Brain uptakes of these two tracers were mea...

BACKGROUND AIMS Endoscopy is the gold standard for the diagnosis and follow-up of patients with Crohn disease (CD). However, a less invasive approach is now being sought for the management of these patients. The objective of this study was to examine whether (18)F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) might be relevant for monitoring the disease activity in CD patients und...

This paper describes Parallel Grammatical Evolution (PGE) that can be together with clustering used for a improvement of the throughput of computer networks. To increase the efficiency of Grammatical Evolution (GE) the influence of backward processing was tested. The significance of backward coding (BC) and the comparison with standard coding of GEs is presented. BC can speed up Grammatical Evo...

The Markovian nature follows readily from a mechanistic view, where complete knowledge of a system and sufficient computational resources will allow us to determine the state of the system – or distribution over possible states for stochastic systems – at any given point in the future. Markovian need not progress in time, in fact, for many bioinformatics applications the progression will be in ...

Objective. To assess fracture resistance and failure mode of repaired fiber-reinforced composite (FRC) cusp-replacing restorations. Methods. Sixteen extracted human premolars with fractured cusp-replacing woven (Group (A)) or unidirectional (Group (B)) FRC restorations from a previous loading experiment were repaired with resin composite and loaded to fracture. Results. Differences in fracture ...

Transformation of tetra(4-cyanophenyl)ethylene under Lewis acidic (ZnCl2) conditions at 400 °C leads to the formation of a porous covalent triazine-based organic framework (CTF) with a high surface area (2235 m(2) g(-1)), high CO2 and CH4 uptakes and the highest hydrogen uptake for a CTF material (1.86 wt% at 77 K, 1 bar).

Acute lymphoblastic leukemia (ALL) with mixed lineage leukemia (MLL) gene rearrangements (MLL+ALL) has a dismal prognosis and is characterized by high surface CD44 expression. Known that CD44 has the specific binding sites for a natural ligand hyaluronan (HA), we investigated biological effects of HA with different molecular sizes on MLL+ALL cell lines, and found that the addition of ultra-low-...