There is evidence that spontaneous migraine headache is associated with changes in 5-hydroxytryptamine (5HT) metabolism. Thus Sicuteri, Testi, and Anselmi (1961) reported grossly elevated urinary excretion of 5-hydroxyindoleacetic acid (5HIAA), the main urinary metabolite of 5HT, by migrainous subjects on days when attacks occurred. Increased excretion was also found by Curran, Hinterberger, an...

An approach to reserpine (1) is described which is based on an anionic oxy-Cope rearrangement to establish three of the five contiguous asymmetric centers of the E ring and a regiospecific enol silylation coupled with hydroboration-oxidation to introduce the last two centers. The key intermediate 8b for the anionic oxy-Cope rearrangement is prepared from the readily available 7,7-dimethoxynorbo...

introduction: the effect of esophageal distension (ed) on gastric motility has been well documented, but a few investigations have been carried out on the effect of ed on gastric secretion. the aim of this study was to investigate the effect of ed on gastric acid and pepsin secretion and the mechanism(s) involved. methods: male adult wistar rats (200-240 g) were anesthetized with urethane (1.2 ...

Sleep is an important physiological state, but its function and regulation remain elusive. In Drosophila melanogaster, a useful model organism for studying sleep, forward genetic screens have identified important sleep-modulating genes and pathways; however, the results of such screens may be limited by developmental abnormalities or lethality associated with mutation of certain genes. To circu...

Fig. 1. Effect of chlorpromazine and reserpine on the arterio-venous dflerence of glutamine and glutamate during qtrerent electrical stimulation Blood samples from the femoral artery and the transverse sinum contralateral to the stimulated plexus were taken simultaneously in the course of the second minute of stimulation, or before stimulation. The stimulation was performed 60min after a single...

Serotonin, a smooth-muscle constrictor, has been suggested as possibly important in the pathogenesis of arterial hypertension. The benzyl analog of serotonin (BAS) was developed as an antimetabolite of serotonin, and has certain demonstrable antiserotonin effects in man. Orally it has mode.ate antihypertensive and other clinical effects resembling those of reserpine, which also has a definite a...

The relative benefits and risks of reserpine and guanethidine were compared in patients with thiazide-treated mild to moderate hypertension (diastolic pressure 95-115 mm Hg). Fortynine ambulant patients (30 men, 19 women) were treated throughout the study with hydrochlorothiazide, 50 mg/day. In this double blind crossover study each drug was added in graded increments until a predetermined ther...

Steric Aspects of Adrenergic Drugs. I. Comparative Effects of DL Isomers and Desoxy Derivatives. P. N. PATIL, J. B. LAPIDUS AND A. TYE 1 Steric Aspects of Adrenergic Drugs. II. Effects of DL Isomers and Desoxy Derivatives on the Reserpine-Pretreated Vas Deferens. P. N. PATIL, J. B. LAPInus, D. CAMPBELL AND A. TYE 13 Steric Aspects of Adrenergic Drugs. III. Sensitization by Cocaine to Isomers of...

The nigrostriatal dopaminergic system seems to be involved in both reserpine-induced orofacial dyskinesia in normal rats and in the pathogenesis of hypertension in spontaneously hypertensive rats. In the present study, repeated reserpine administration (1.0 mg/kg, s.c., every other day, for 3 days) increased tongue protrusion and vacuous chewing frequencies as well as the duration of facial twi...

1. The interactions of dopamine, reserpine and methyldopa on blood pressure of normal subjects and of those with essential hypertension were examined. 2. When biosynthesis of noradrenaline from dopamine was blocked by reserpine, dopamine induced a prominent depressor effect in essential hypertension. 3. The long-term treatment with methyldopa induced a marked potentiateion of the pressor action...