Magnetic resonance imaging (MRI), used as a clinical diagnostic tool since the early 1980s, is rapidly gaining traction as an integral part of the drug development process. Brain imaging research spans a wide area, covering both structure and function, and ranging from the physics and physiology associated with novel acquisition techniques, to the development of sophisticated image processing a...

Background: Observing the enhancing plaques in magnetic resonance imaging (MRI) is one of the most valuable diagnostic modalities in confirming the diagnosis of multiple sclerosis (MS), its recurrence and for better detection of active disease. Since active lesions discovery can improve designating diffusion in time diagnosis of MS and controlling disease activity, and there is not any definite...

We present a case of combined central and peripheral demyelination in patient with pediatric multiple sclerosis after the first dose ChAdOx1-S (Chimpanzee Adenovirus Oxford 1) vaccination. The presented ascending flaccid quadriparesis respiratory failure that required mechanical ventilation. lumbar puncture revealed albuminocytological dissociation, was negative for presence JCV (John Cunningha...

balo's concentric multiple scleroses (ms) is a rare demyelinating disease and a variant of multiple sclerosis. we report a case with interesting misleading clinical history and typical ri findings of balo disease. a 19-year-old girl presented with fever and left hemiparesis following dental procedure 15 days ago. on physical examination fever and left limbs forces loss were noted. on ct scan a ...

rhabdomyosarcoma is a common primary childhood malignancy that rarely metastasizes to the breast. we report a patient with a primary sinonasal rhabdomyosarcoma metastasizing to the breast, with no distant spread. we describe the imaging appearance of rhabdomyosarcoma on magnetic resonance imaging (mri), particularly on diffusion-weighted imaging (dwi) and apparent diffusion coefficient (adc) se...

The advent of magnetic resonance imaging (MRI) has revolutionized concepts of the pathogenesis of multiple sclerosis (MS). Magnetic resonance imaging provides the ability to delineate the evolution of the disease process over time; captured static snapshots can then be used in pathologic correlations studies. Certain patterns in the 2- or 3-dimensional MRI sphere correlate very well with simila...

Automated quality control (QC) procedures are critical for efficiently obtaining precise quantitative brain imaging-based metrics of in vivo brain pathology. This is especially important for multi-centre clinical trials of therapeutics for neurological diseases, in which brain imaging-based metrics may be used to quantify therapeutic efficacy. While there are many different types of brain imagi...

There are exciting new advances in multiple sclerosis (MS) resulting in a growing understanding of both the complexity of the disorder and the relative involvement of grey matter, white matter and inflammation. Increasing need for preclinical imaging is anticipated, as animal models provide insights into the pathophysiology of the disease. Magnetic resonance (MR) is the key imaging tool used to...

BACKGROUND In the Betaseron/Betaferon in Newly Emerging Multiple Sclerosis for Initial Treatment (BENEFIT) study, interferon beta-1b delayed conversion to multiple sclerosis in patients with a first clinical event and at least 2 clinically silent brain magnetic resonance imaging (MRI) lesions. OBJECTIVE To examine detailed MRI findings from the first 2 years of this trial. DESIGN Double-bli...

Objective: To evaluate magnetic resonance imaging (MRI) of multiple sclerosis (MS) patients in Thailand. Method: A retrospective review on the initial brain and spinal cord MRI in MS patients was done but primary progressive MS and the AQP4 antibody positive patients were excluded. The characteristics of brain and spinal cord MRI were analyzed. Results: For the initial brain MRI studies, fi fty...