purpose: to determine globe and patient survival in children with retinoblastoma at a major referral center in iran. methods: hospital records of 156 eyes of 105 patients with retinoblastoma referred to the ocular oncology center at rasoul akram hospital, tehran, iran from 2001 to 2007 were reviewed. demographic data, family history, presenting symptoms, duration of symptoms, ocular findings an...

purpose: the aim of the present study was to detect the expression of p-glycoprotein (p-gp) and multi-drug resistance associated protein 1 (mrp1) in retinoblastoma tumors, and analyze the relationship between its expression, the clinico-pathological features and recurrence. methods: p-gp and mrp1 expression in formalin-fixed paraffin-embedded retinoblastoma bearing ocular tissue sections from 2...

BACKGROUND Plants are the valuable source of natural products with important medicinal properties. Most of the approved anti cancer drugs have a natural product origin or are natural products. Retinoblastoma is the most common ocular cancer of children. Although chemotherapy is the preferred mode of therapy, a successful treatment for retinoblastoma requires enucleation. Chebulagic acid (CA) fr...

BACKGROUND In our clinical experience we discovered that EEG band power may be correlated with corneal nerve injury in retinoblastoma patients. This study aimed to investigate biomarkers obtained from electroencephalography (EEG) recordings to reflect corneal nerve injury in retinoblastoma patients. MATERIAL AND METHODS Our study included 20 retinoblastoma patients treated at the Department of ...

Missing evidences in cancer genetics: The retinoblastoma paradigm * Sir, Retinoblastoma (Rb) is the most common primary malignant intraocular tumour in childhood, with an incidence of 1 in 15,000 live births. It essentially affects the retina of young children under the age of five years, and may involve one eye (unilateral retinoblastoma) or both (bilateral retinoblastoma). Retinoblastoma is c...

Introduction: Retinoblastoma is the most common intraocular tumor in child. The treatment well codified combining chemotherapy, surgery, radiotherapy and conservative treatment. It involves both visual vital prognosis. aim of this study was to describe epidemiological aspect retinoblastoma evaluate therapeutic aspects evolution Madagascar.
 Method: We report retrospective 52 cases found du...

5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR), an analog of AMP is widely used as an activator of AMP-kinase (AMPK), a protein that regulates the responses of the cell to energy change. Recently, we showed that AICAR-induced AMPK activation inhibits the growth of retinoblastoma cells in vitro by decreasing cyclins and by inducing apoptosis and S-phase arrest. In this study, we inv...

BACKGROUND Retinoblastoma is the most frequent tumor of the eye in children and very little is known about the etiology of non-familial (sporadic) retinoblastoma. In this study we examined whether parental tobacco smoking or alcohol consumption (pre- or post-conception) contribute to the two phenotypes (bilateral or unilateral) of sporadic retinoblastoma. METHODS Two large multicenter case-co...

BACKGROUND: Retinoblastoma (RB) is the most common childhood eye cancer. Chemotherapeutic drugs such as etoposide used in RB treatment often cause massive side effects and acquired drug resistances. Dysregulated genes miRNAs have a large impact on cancer progression development of chemotherapy OBJECTIVE: This study was designed to investigate involvement retinoic acid receptor alpha (RARα) chem...

Case presentation: Patient was the first child of non-consanguineous parents whose father healthy, but mother had mild intellectual deficiency and spastic paraparethic gait that been attributed to cerebral palsy. At birth he presented congenital talipes equinovarus. He began crawl at 1yo never able walk independently despite orthopedic feet correction. 1yo, leukocoria in left eye noticed. Bilat...