Brucella melitensis Rev 1 is the best vaccine available for the prophylaxis of small ruminant brucellosis and, indirectly, for reducing human brucellosis. However, Rev 1 shows anomalously high rates of spontaneous dissociation from smooth (S) to rough (R) bacteria, the latter being inefficacious as vaccines. This S-R instability results from the loss of the O-polysaccharide. To overcome this pr...

Astrocytes are target cells for human immunodeficiency virus type 1 (HIV-1) in the central nervous system with attenuated virus replication in vivo and in vitro. In infected astrocytes, viral gene expression is restricted mainly to nonstructural (early) viral components like Nef, suggesting inhibition of Rev-dependent posttranscriptional processes in these cells. Because of the heterogeneity of...

The 26S proteasome is a large multisubunit proteolytic complex, regulating growth and development in eukaryotes by selective removal of short-lived regulatory proteins. Here, it is shown that the 26S proteasome and the transcription factor gene REVOLUTA (REV) act together in maintaining inflorescence and floral meristem (IM and FM) functions. The characterization of a newly identified Arabidops...

s of the American Physical Society, 1993 (American Physical Society, Ridge, NY, 1993). [14] G. L. Greene, E. G. Kessler, Jr., R. D. Deslattes, and H. Börner, Phys. Rev. Lett. 56, 819 (1986). [15] D. Weiss, B. Young, and S. Chu, Phys. Rev. Lett. 70, 2706 (1993); Appl. Phys. B 59, 217 (1994). [16] Th. Udem, J. Reichert, R. Holzwarth, and T. W. Hänsch, Phys. Rev. Lett. 82, 3568 (1999). [17] B. C. ...

The viral transactivator Rev is essential for HIV replication, since it allows the nuclear export of unspliced and partially spliced viral mRNAs that encode the structural proteins. Rev is an RNA binding protein that interacts with a highly structured RNA element, the RRE, found within the envelope sequences. This viral protein also interacts with cellular proteins, termed nucleoporins, and act...

Publications in refereed journals 1 Observation of e+e− annihilations into the C = +1 hadronic final states ρρ and φρ B. Aubert et al. [BABAR Collaboration], Phys. Rev. Lett. 97, 112002 (2006). 2 Search for the decay B → K SK SK L B. Aubert et al. [BABAR Collaboration], Phys. Rev. D 74, 032005 (2006). 3 Search for doubly charmed baryons Ξcc and Ξ ++ cc in BABAR B. Aubert et al. [BABAR Collabora...

to s,Trio+'4'(y, )4'(y,)]. The expansion of the operator product contains terms proportional to the scalar gluon field y(x) such as Iyi y-. l' "'~ "+'s (y, y-.)ly, -y, l 'J''«~(~)8 (o, y„~y, +(&-~)y, ). This quark-antiquark singularity leads to a term in 6'(x, k) that falls off as 6'„(x,k) ~ Ikl' '"" ' ~ ' = Ikl '. R. Blankenbecler, Phys. Rev. D 8, 287 (1978); S. J. Brodsky, F. E. Close, and J....

Intracellular immunization to target the human immunodeficiency virus type 1 (HIV-1) regulatory protein Rev has been explored as a genetic therapy for AIDS. Efficient intracellular expression of rearranged immunoglobulin heavy and light chain variable regions of anti-Rev monoclonal antibodies, with various vectors, and subsequent inhibition of HIV-1 replication have been previously reported by ...