May I suggest that the ALL-REZ BFM 90 study published recently in Blood1 may be interpreted differently from that presented? The study results are not unexpected (no improvement in cure rate with either dose) because both doses of methotrexate (MTX) used were suboptimal. A cerebral spinal fluid (CSF) level of 1 molar is usually accepted as the required effective level in newly diagnosed ALL obt...

ER5 Helen W. Belding,M.D., Winston-Salem, N. C. Conrad Maier, M.D., Zurich, Switzerland Sheila T. Callender,M.D.,Oxford, England Milos Netou ek,M.D.,Prague, Czechoslovakia Robert B. Chodos M.D. Framingham Mass. Charles E. Rath, M.D., Washington . . . Jean P. Soulier M.D. Paris France Roger C. Crafts, Ph.D., Cincinnati , RamonM.Su#{225}rez M.D. SanJuan PuertoRrco C. R. DasGupta, M.D., Calcutta, ...

r e s u M e n Para examinar las condiciones bajo las cuales una muestra de participantes del público general y de profesionales de la salud chilenos considera aceptable que un médico rompa la confidencialidad para proteger al cónyuge de un paciente que padece una enfermedad de transmisión sexual (ETS), doscientos siete participantes (personas del público general y profesionales de la salud), ev...

a m o d e r n i d i o m . M o r e c lass ica l i n f l u e n c e s , espec ia l ly t h o s e of G e o r g e B a l a n c h i n e , a r e e v i d e n t in " S y m p h o n y in D . " T h e r e a r e p a r o d i e s of m i m e scenes f r o m all of t h e o ld " s t o r y " ba l le t s . At o n e p o i n t , all e i g h t m e n in t he ba l le t b u r s t o n t o t he s t age a n d a s s u m e t h e...

Relapse of T-cell acute lymphoblastic leukemia (T-ALL) has a dismal prognosis, with only 20% of afflicted children surviving. Children with relapsed T-ALL are commonly treated within high-risk arms of second-line treatment protocols that include mandatory hematopoietic stem cell transplantation (HSCT) if a second complete remission can be induced. Second-line treatment, however, fails in 80% of...

J.Pietraszko1, L. Fabbietti2, F. Guber3, A. Ivashkin3, A. Kugler4, K. Lapidus2, E. Lisowski6, A. Reshetin3, P. Salabura5, Yu.G. Sobolev4, P. Tlusty4, and the HADES collaboration.. 1Institut für Kernphysik, Goethe-Universität Frankfurt, Germany; 2Excellence Cluster Origin and Structure of the Universe, 85748 München, Germany; 3Institute for Nuclear Research, Russian Academy of Science, 117312 Mo...

ER5 Helen W. Belding,M.D., Winston-Salem, N. C. Conrad Maier, M.D., Zurich, Switzerland Sheila T. Callender,M.D.,Oxford, England Milos Netou ek,M.D.,Prague, Czechoslovakia Robert B. Chodos M.D. Framingham Mass. Charles E. Rath, M.D., Washington . . . Jean P. Soulier M.D. Paris France Roger C. Crafts, Ph.D., Cincinnati , RamonM.Su#{225}rez M.D. SanJuan PuertoRrco C. R. DasGupta, M.D., Calcutta, ...

Stereochemistry is an issue of great relevance in both technological and fundamental disciplines. For instance, many biological molecules present a characteristic chiral structure, which make them suitable for targeting singleenantiomer drugs. Also of basic importance in the framework of the origin of life, it is accepted that a first enantiomeric selection process took place at some stage on t...

ERS HelenW.Belding,M.D., Winston-Salem.N.C. Conrad Maier, M.D., Zurich, Switzerland Sheila T. Callender, M.D., Oxford, England Milo Xetou ek,M.D., Praha, Czechoslovakia Robert B. Chodos, M.D., Franninghain, Mass. Charles E. Rath, M.D., Washington Roger C. Crafts, Ph.D., Cincinnati Jean P. Soulier, M.D., Paris, France C. R. DasGupta, M.D ., Calcutta, India Ram#{243}n M. Su#{225}rez,M.D.,SanJuan,...

ERS HelenW.Belding,M.D., Winston-Salem.N.C. Conrad Maier, M.D., Zurich, Switzerland Sheila T. Callender, M.D., Oxford, England Milo Xetou ek,M.D., Praha, Czechoslovakia Robert B. Chodos, M.D., Franninghain, Mass. Charles E. Rath, M.D., Washington Roger C. Crafts, Ph.D., Cincinnati Jean P. Soulier, M.D., Paris, France C. R. DasGupta, M.D ., Calcutta, India Ram#{243}n M. Su#{225}rez,M.D.,SanJuan,...