Abstract Background Pseudomonas aeruginosa is a common opportunistic pathogenic bacterium with the ability to develop strong communication pathway by quorum sensing system and different virulent factors. Among various important secretions of P. rhamnolipid biological detergent, believed be involved in development biofilm intercellular communication. It readily dissolves lung surfactants that ar...

Two quorum-sensing systems (las and rhl) regulate virulence gene expression in Pseudomonas aeruginosa. The las system consists of a transcriptional activator, LasR, and LasI, which directs the synthesis of the autoinducer N-(3-oxododecanoyl) homoserine lactone (PAI-1). Induction of lasB (encoding elastase) and other virulence genes requires LasR and PAI-1. The rhl system consists of a putative ...