Background: Anti-CCP is a test commonly used for the diagnosis of rheumatoid arthritis. The aim of this study was to determine the diagnostic values of ACCP compared to anti-MCV in rheumatoid arthritis patients in north of Iran. Methods: The serum samples of 150 RA patients and 75 controls, with the mean age of 49.6+11.8 and 48.8+12 years respectively, were tested using the commercially availa...

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is an adverse drug reaction described as the progressive destruction and death of bone tissue of the mandible or maxilla, in the course of bisphosphonate therapy. Orally administered bisphosphonates, widely used for the treatment of osteoporosis, are rarely associated with BRONJ. Instead, the risk greatly increases whether the patient is c...

Alterations in osteoblast growth, differentiation and activity play a role in the pathogenesis of several rheumatic diseases, such as rheumatoid arthritis, spondyloarthritides, osteoarthritis, and osteoporosis. In fact, in these rheumatic diseases, abnormal activity of Wnt signaling, receptor activator of nuclear factor-κB (RANK)-RANK ligand (RANKL)-osteoprotegerin (OPG) signaling, bone morphog...

Viewpoint 1268 Clinical trials of new drugs for the treatment of rheumatoid arthritis: focus on early disease J S Smolen, S C Basset, M Boers, F Breedveld, C J Edwards, T K Kvien, P Miossec, T Sokka-Isler, R F van Vollenhoven, E C Abadie, O Bruyère, C Cooper, H Mäkinen, T Thomas, P Tugwell, J-Y Reginster, on behalf of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteo...

rheumatoid arthritis is the most common inflammatory joint disease with 1 percent prevalence in community which presents with symmetrical polyarthritis of hands with inflammatory behavior. several studies in recent years were conducted for evaluation of inflammatory cytokines such as il1-α (interlukin 1α) and tnf- α (tumor necrosis factor) in rheumatologic disorders including rheumatoid arthrit...

INTRODUCTION Postmenopausal women with rheumatoid arthritis (RA) have increased risk of developing osteoporosis due to chronic inflammation and estrogen deprivation. Collagen antibody-induced arthritis (CAIA), an experimental polyarthritis model representing the effector phase of arthritis, is mainly mediated by the innate immune system. Compared to the widely used collagen-induced arthritis mo...

background and aim: autoimmune inner ear disease (aied) may accompany certain systemic conditions, such as rheumatoid arth­ritis, and manifest audiovestibular dysfunction. this study aimed to compare the vestibular function between rheumatoid arthritis (ra) patients and normal subjects using cervical vestibular-evoked myogenic potentials and caloric tests. methods: in this cross-sectional study...