<p class="abstract">In the midst of severe acute respiratory syndrome coronavirus 2 (SARS COV-2) pandemic, victims are acquiring secondary infections like mucormycosis. Rhinocerebral mucormycosis (ROCM), is most prevalent form and an invasive, opportunistic fungal infection that typically affects immunocompromised patients. It exhibits a pronounced propensity to invade blood arteries, res...

TOPIC: Critical Care TYPE: Medical Student/Resident Case Reports INTRODUCTION: Rhinocerebral mucormycosis is a fatal infection in poorly controlled diabetic patients with history of ketoacidosis (DKA). DKA blunts neutrophil chemotaxis, phagocytosis and boosts serum iron, mucor nutrient. It spreads to the brain via hematogenous or contiguous spread [1]. We present case disseminated rhinocerebral...

Figure 1. Total WBC count (0) and ANC (e) for patient 1, a 37year-old male who developed vancomycin-induced neutropenia. G-CSF (600 f.Lg iv) was initially administered on days 30 and 33 of therapy. Additional 300-f.Lg doses of iv G-CSF were administered twice weekly (on days 38-52) and thrice weekly (on days 55-78) until vancomycin therapy was completed. ANC = absolute neutrophil count. 8,500

NCCLS, Villanova, PA, USA, 2001. 3. Weill FX, Bertrand S, Guesnier F et al. Ciprofloxacinresistant Salmonella Kentucky in travelers. Emerg Infect Dis 2006; 12: 1611–2. 4. Baucheron S, Imberechts H, Chaslus-Dancla E et al. The AcrB multidrug transporter plays a major role in high-level fluoroquinolone resistance in Salmonella enterica serovar Typhimurium phage type DT204. Microb Drug Resist 2002...

An extracellular aspartic proteinase (Rmap) from Rhizopus microsporus var. rhizopodiformis was detected in the culture supernatant of a fungal isolate from a case of rhinocerebral mucormycosis (case HA). The proteinase was purified to near homogeneity by ion exchange and affinity chromatography on pepstatin agarose. Based on its N-terminus the RMAP gene was cloned and found to code for 388 amin...

The most common clinical presentation of mucormycosis is rhino-orbital-cerebral infection, which is supposed to begin with inhalation of spores into the paranasal sinuses of a vulnerable host. Hyperglycemia, with an associated metabolic acidosis, is the most common underlying state.1 The hallmarks of spread outside the sinuses are tissue necrosis of the palate.1,2 We present a 57-year-old man a...