Munc13 proteins are essential regulators of exocytosis. In hippocampal glutamatergic neurons, the genetic deletion of Munc13s results in the complete loss of primed synaptic vesicles (SVs) in direct contact with the presynaptic active zone membrane, and in a total block of neurotransmitter release. Similarly drastic consequences of Munc13 loss are detectable in hippocampal and striatal GABAergi...

During gene transcription, the RNA polymerase (Pol) active center can catalyze RNA cleavage. This intrinsic cleavage activity is strong for Pol I and Pol III but very weak for Pol II. The reason for this difference is unclear because the active centers of the polymerases are virtually identical. Here we show that Pol II gains strong cleavage activity when the C-terminal zinc ribbon domain (C-ri...

Hearing depends on reliable and temporally precise neurotransmission by cochlear hair cells. The wide dynamic range and high sensitivity with which these cells encode acoustic stimuli are associated with a presynaptic specialization termed the presynaptic dense body or synaptic ribbon. Apposed to the presynaptic density, this spherical or flattened structure tethers a layer of synaptic vesicles...

Narrow, inextensible, and naturally flat ribbons have some special and interesting phenomena under isometric deformations. Although a ribbon has a shape between rod and shell, directly applying the geometric representation designed for them imposes a challenge to faithfully reproduce interesting behaviors. We thus parameterize the ribbon surface as a developable ruled surface along its centerli...

Motivated by a diversity of the shape instability phenomena in condensed-matter physics, we study the formation of elastic ribbon structures and transformation into helicoidal structures. Using the multipulse laser-matter interaction with the Co-coated surface, a one-dimensional high-density vortex-filament array has been created. Increasing the number of pulses, the oscillatory strain field ca...

Width-controlled M-type hexagonal SrFe12O19 nanoribbons were synthesized for the first time via polyvinylpyrrolidone (PVP) sol assisted electrospinning followed by heat treatment in air, and their chemical composition, microstructure and magnetic performance were investigated. Results demonstrated that as-obtained SrFe12O19 nanoribbons were well-crystallized with high purity. Each nanoribbon wa...