Small Leucine-Rich Proteoglyans (SLRPs) are major skeletal extracellular matrix (ECM) components that comprise a family of 13 members containing repeats of a leucine-rich motif. To examine SLRP function, we generated mice deficient in one or more member and analyzed them at the tissue, cell and molecular levels. This review outlines the novel research findings uncovered using these new animal m...

The representation of hierarchically structured knowledge in systems using distributed patterns of activity is an abiding concern for the connectionist solution of cognitively rich problems. Here, we use statistical unsupervised learning to consider semantic aspects of structured knowledge representation. We meld unsupervised learning notions formulated for multilinear models with tensor produc...

We present an approach for generation of morphologically rich languages using statistical machine translation. Given a sequence of lemmas and any subset of morphological features, we produce the inflected word forms. Testing on Arabic, a morphologically rich language, our models can reach 92.1% accuracy starting only with lemmas, and 98.9% accuracy if all the gold features are provided.

Bacteria offer an evolutionary model in which rich interactions between phenotype and genotype lead to compact genomes with efficient metabolic pathways. Central to this is the expression and folding of sequences of amino acids to form proteins. We seek an analogous process that supports a rich artificial heredity. These systems can be simulated by stochastic chemistry models, but there is curr...

We discuss the existence of a mass-metallicity relation among galactic halo globular clusters. The lack of any luminosity-metallicity correlation in globular cluster systems has been used as an argument against self-enrichment models of cluster formation. We show that such a relation is statistically present among the galactic Old Halo globulars. This observational correlation implies that the ...

We present a method for unsupervised opendomain relation discovery. In contrast to previous (mostly generative and agglomerative clustering) approaches, our model relies on rich contextual features and makes minimal independence assumptions. The model is composed of two parts: a feature-rich relation extractor, which predicts a semantic relation between two entities, and a factorization model, ...

It has frequently been proposed that a variation in the relative content of lysine-rich, moderately lysine-rich, and arginine-rich histones might provide a mechanism by which specific portions of the genome may be genetically regulated. This possibility was investigated by comparing the electrophoretic pattern of these three fractions in cells differing markedly in their content of genetically ...

Experiments on fracture surface morphologies offer increasing amounts of data that can be analyzed using methods of statistical physics. One finds scaling exponents associated with correlation and structure functions, indicating a rich phenomenology of anomalous scaling. We argue that traditional models of fracture fail to reproduce this rich phenomenology and new ideas and concepts are called ...