During inflammation, chemokines are conductors of lymphocyte trafficking. The chemokine CXCL10 is expressed early after virus infection. In a virus-induced mouse model for type 1 diabetes, CXCL10 blockade abrogated disease by interfering with trafficking of autoaggressive lymphocytes to the pancreas. We have generated transgenic rat insulin promotor (RIP)-CXCL10 mice expressing CXCL10 in the be...

Traditional routing protocol designs have focused solely on the functionality of the protocols and implicitly assume that all routing update messages received by a router carry valid information. However operational experience suggests that hardware faults, software implementation bugs, operator misconfigurations, let alone malicious attacks can all lead to invalid routing protocol announcement...

To mimic events and molecules involved in type 1 insulin-dependent diabetes mellitus (T1D), we previously designed a transgenic (tg) mouse model where the viral nucleoprotein (NP) gene of lymphocytic choriomeningitis virus (LCMV) was expressed in the thymus to delete high affinity antiself (virus) T cells and in insulin-producing beta cells of the islets of Langerhans. Such tg mice, termed RIP-...

The aim of the present study was to elucidate the intracellular mechanisms that cause neuronal cell death following exposure to excitatory neurotransmitter‑induced neurotoxicity, neurotoxins and oxidative stress. Human SH‑SY5Y neuroblastoma cells were exposed to various stimuli, including glutamate, 6‑hydroxydopamine (6‑OHDA), and glucose oxidase, and cell viability was determined by MTT assay....

OBJECTIVE To determine the sensitivity and specificity of quantitative respiratory inductive plethysmography (RIP) compared with the "gold standard," nocturnal esophageal pressure (Pes) measurement, in the diagnosis of upper airway resistance syndrome (UARS) in adults. METHODS Fourteen consecutive patients without obstructive sleep apnea and suspected of having UARS underwent simultaneous mea...

Abstract Rip currents represent significant hazards to swimmers all around the world. The danger arises when a misinformed swimmer uses an inadequate strategy escape rip, such as fighting current directly. This can lead fatigue, panic, and in some cases drowning. There exists range of strategies put forward by experts (both lifeguards scientists) rip currents. However, these recommendations are...

The relative expression patterns of maize (Zea mays L.) ribosome-inactivating protein 1 (RIP1)/type 3 ribosome-inactivating protein transcript were analyzed using reverse transcription and polymerase chain reaction (RT-PCR) with template materials collected separately from mature and immature root, leaf and seed tissues. The presence of RIP transcript was only detected in mature seed and immatu...

Ureteral stents coated with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rat bladders and shown to suppress Staphylococcus aureus formation on the stent and in urine and was especially effective when combined with teicoplanin. Coating ureteral stents with RIP thus increases the efficacy of teicoplanin in preventing ureteral stent-associated staphylococcal infec...

We show that RIP frames, tight frames satisfying the restricted isometry property, give rise to nearly tight fusion frames which are nearly orthogonal and hence are nearly equi-isoclinic. We also show how to replace parts of the RIP frame with orthonormal sets while maintaining the restricted isometry property.

The long-term goals of this research are to understand the dynamics of rip currents generated by largescale variations in alongshore pressure gradients and wave forcing, and the impact of rip currents on nearshore bathymetry. These goals will be accomplished collaboratively using field observations obtained as part of the Nearshore Canyon Experiment (NCEX) held in the fall of 2003 and with nume...