Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and is divided into two major histological subgroups, i.e., embryonal (ERMS) and alveolar RMS (ARMS). RMS can show HEDGEHOG/SMOOTHENED (HH/SMO) signaling activity and several clinical trials using HH inhibitors for therapy of RMS have been launched. We here compared the antitumoral effects of the SMO inhibitors GDC-0449, ...

The purpose of this study is to investigate whether medication and deep brain stimulation (DBS) have differential effects on the speed and amplitude of bradykinesia in patients with Parkinson's disease (PD). Five PD patients with implanted DBS electrodes (age: 60.6 ± 7.4 yrs, H&Y stage: 3.1 ± 0.2) participated in this study. FT (finger tapping) movement was measured using a gyrosensor system in...

Theoretical research in international trade increasingly focuses on …rm heterogeneity in di¤erentiated product markets following Melitz (2003). A key implication of this line of research is that …rms are unevenly affected by trade liberalization: low productivity …rms exit, intermediate-productivity domestic …rms contract, and high-productivity exporting …rms expand. More recent theoretical res...

Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation technique that can alter cortical excitability in human subjects for hours beyond the stimulation period. It thus has potential as a therapeutic tool in neuropsychiatric disorders associated with alterations in cortical excitability. However, rTMS-induced neural plasticity remains insufficiently understood at...

Necrotizing enterocolitis (NEC) is the most common gastrointestinal disease of prematurely born infants. Maternal milk plays an important protective role against NEC development and is the major source of epidermal growth factor (EGF) for neonates. The aim of this study was to examine the effect of orally administered EGF on the incidence of NEC in a neonatal rat model. Newborn rats were artifi...

The Notch pathway regulates a broad spectrum of cell fate decisions and differentiation processes during fetal and postnatal development. In addition, the Notch pathway plays an important role in controlling tumorigenesis. However, the role of RBPJ, a transcription factor in the Notch pathway, in the development of tumors is largely unknown. In this study, we focused on the role of RBPJ in the ...

This paper compares the e¢ ciency implications of aggregate output equivalent unit versus advalorem tax regimes when monopolistically competitive …rms produce di¤erentiated products with either homogenous or heterogenous costs. The model allows for …rms to price at a variable markup over marginal cost. In line with most prior …ndings the superiority of ad-valorem tax continues to hold when …rms...

The presence of neural stem cells in the adult brain is currently widely accepted and efforts are made to harness the regenerative potential of these cells. The dentate gyrus of the hippocampal formation, and the subventricular zone (SVZ) of the anterior lateral ventricles, are considered the main loci of adult neurogenesis. The rostral migratory stream (RMS) is the structure funneling SVZ prog...

As Residências Multiprofissionais em Saúde (RMS) vêm sendo cada vez mais consideradas como uma importante alternativa de formação dos profissionais saúde para o arranjo novos desenhos tecnoassistenciais. A Educação Interprofissional (EIP) ocorre quando duas ou profissões aprendem com, a partir e sobre outra com objetivo comum melhorar colaboração no trabalho equipe. Pode se inserir contexto das...