Axonal injury due to prostatectomy leads to Wallerian degeneration of the cavernous nerve (CN) and erectile dysfunction (ED). Return of potency is dependent on axonal regeneration and reinnervation of the penis. Following CN injury (CNI), RhoA and Rho-associated protein kinase (ROCK) increase in penile endothelial and smooth muscle cells. Previous studies indicate that nerve regeneration is ham...

Field and laboratory studies have indicated that rock fragments in the topsoil may have a large impact on soil properties, soil quality, hydraulic, hydrological and erosion processes. In most studies, the investigated rock fragments still remain visible at the soil surface and only properties of these visible rock fragments are used for predicting runoff and soil loss. However, there are indica...

Analysis of advanced displacement in construction progress of tunnel excavation with weak surrounding rock is carried out by numerical method and comparison of model test result. In allusion to the problems of regional landslides and extruded large-deformation seriously impacting the stability of rock mass in construction process of large-section tunnel with weak surrounding rock, the elastic-p...

* Corresponding author – [email protected] Tel: 414-229-4126 Fax:414-229-6958 ABSTRACT Understanding the fundamental tribology associated with the cutting of rock under extremely high pressure and high temperature (HPHT) conditions are extremely important in mining and drilling operations. In this paper, a rock fragmentation process is simulated during mechanical cutting of rock using an explicit...

The rocks are formed through very complex processes and the complex behaviour of rock masses is dominated by the planes of weaknesses . Rock mass consists of intact rock and discontinuities. Many rocks show strain softening behaviour under loads. In this paper, the constitutive models for intact rocks and rock joints are presented. These form the basis for the development of constitutive models...

Excitable cattle are dangerous to personnel and have reduced individual performance. The aim of this study was to 1) identify objective criteria for evaluating bull temperament and 2) examine relationships among temperament, behavior, and performance of bulls during an 84-d performance test. Angus bulls ( = 60) were reared in 6 pens based on BW and age. Pen scores (PS; 1 = docile and 5 = very a...

To effectively select for temperament, selection criteria must reflect an animal's response to stress. Subjective measures such as chute (CS) and exit (ES) score provide fast easy assessments of temperament but may be subject observer bias inconsistency. Objective cortisol other metabolites have been associated with increased stress in cattle, especially regarding transportation. Our objectives...

Chaque année, 90 000 personnes âgées de 65 ans ou plus se blessent lors d’une chute. Le portail en ligne bpa.ch/parachutes du Bureau prévention des accidents (BPA) met à disposition tous les outils et connaissances nécessaires pour permettre aux spécialistes prévenir chutes. Cela vient soutenir la mise œuvre réussie l’indicateur qualité recommandé par SSMIG «Identification risques chutes préven...

Rho-Rho kinase (Rho-ROCK) triggers an intracellular signalling cascade that regulates cell survival, death, adhesion, migration, neurite outgrowth and retraction and influences the generation and development of several neurological disorders. Although Fasudil, a ROCK inhibitor, effectively suppressed encephalomyelitis (EAE), certain side effects may limit its clinical use. A novel and efficient...

Rho-associated kinase (ROCK) signaling plays a fundamental role in regulating cell morphology, adhesion, and motility. Aberrant expression of ROCK is related to tumor metastases and poor clinical outcome. Here, we show that ROCK expression is increased in metastatic human mammary tumors and breast cancer cell lines compared with nonmetastatic tumors and cell lines. Overexpression of ROCK confer...