Many key cellular functions, such as cell motility and cellular differentiation are mediated by Rho-associated protein kinases (ROCKs). Numerous studies have been conducted to examine the ROCK signal transduction pathways involved in these motile and contractile events with the aid of pharmacological inhibitors such as Y-27632. However the molecular mechanism of action of Y-27632 has not been f...

according to the former researcher’s presented relations for flow through rock-fill porous media, the effects of physical characteristics was not studied separately. hence, due to the application of these relations, physical characteristics of porous materials effect must be investigated separately. in various constructed physical models of porous media, the effect of several variables such as ...

Rho-associated kinase (ROCK) signaling plays a fundamental role in regulating cell morphology, adhesion, and motility. Aberrant expression of ROCK is related to tumor metastases and poor clinical outcome. Here, we show that ROCK expression is increased in metastatic human mammary tumors and breast cancer cell lines compared with nonmetastatic tumors and cell lines. Overexpression of ROCK confer...

Permeability at high temperature is a very important parameter to be considered for designing underground high level nuclear waste repository (HLW) in rock mass. The surrounding rock mass is exposed to heat radiated by HLW when it is buried underground and development or extension of micro-cracks takes place in the host rock due to rise in temperature. Keeping this in view, the permeability stu...

The Rho/ROCK pathway plays important roles in the modulation of the cytoskeletal integrity of cells, the synthesis of extracellular matrix components in the aqueous humor outflow tissue and the permeability of Schlemm's canal endothelial cells. The activation of the Rho/ROCK pathway results in trabecular meshwork (TM) contraction, and the inhibition of this pathway would provoke relaxation of T...

The sharp change of stiffness in the soil-rock combination stratum is weak point seismic design tunnel structure. To explore influence vibration on shield tunnel, section Jinan rail transit line 4 at Olympic Sports Center used as research background. Firstly, two-dimensional numerical model established, and internal force calculation distribution law structure are studied. Then, based third sim...

SINCE MYOCARDIAL INFARCT SIZE is the major contributor to the development of heart failure, interventions aiming to limit irreversible damage of ischemic myocardium are essential. In the clinical setting, reduction of myocardial oxygen demand and restoration of blood flow to the ischemic myocardium remain the primary targets to accomplish this goal, despite experimental evidence that reperfusio...

background and objectives: in the last few decades, losses of our cultural heritage due to biodeteriorationare beinghighly recognized. from museum objects to rock monuments, the microbial biodeterioration agents are found to be the most destructive. possibilities for proper preservative measure(s) are always more when it is only a monument, statue, museum article, or pre-historic art in any sma...

Laboratory tests were performed on 54 large size specimens of jointed rock mass under uniaxial loading conditions. Based on this experimental study, a methodology has been suggested to estimate strength and tangent modulus of rock masses through a weakness coefficient. The methodology involves mapping of joints in the field and laboratory testing of intact rock specimens to arrive at rock mass ...