The mechanism for the basal targeting of the Miranda (Mira) complex during the asymmetric division of Drosophila neuroblasts (NBs) is yet to be fully understood. We have identified conserved Phosphotyrosyl phosphatase activator (PTPA) as a novel mediator for the basal localization of the Mira complex in larval brain NBs. In mutant Ptpa NBs, Mira remains cytoplasmic during early mitosis and its ...

Cell contractility and migration by integrins depends on precise regulation of protein tyrosine kinase and Rho-family GTPase activities in specific spatiotemporal patterns. Here we show that protein tyrosine phosphatase PTP1B cooperates with β3 integrin to activate the Src/FAK signalling pathway which represses RhoAmyosin-dependent contractility. Using PTP1B null (KO) cells and PTP1B reconstitu...

Patients with suspected complications of gallstone disease should be evaluated for alternative diagnoses, as well as complications of gallstones such as pancreatitis and cholangitis. Laboratory evaluation for all these patients should include a complete blood count, basic serum chemistries, liver function tests, serum amylase and lipase, and urinalysis. A urine pregnancy test should always be p...

BACKGROUND Approximately 90% of new tuberculosis (TB) cases notified in Norway are asylum seekers and other immigrants from high-incidence countries. Asylum seekers are screened upon arrival at the National Immigration Centre. Other immigrants receive a letter from the Municipal Health Services requesting that they present for screening in their municipality of residence. In order to identify p...

A long-standing question in the planetary sciences asks what the Earth is made of. For historical reasons, volatile-depleted primitive materials similar to current chondritic meteorites were long considered to provide the `building blocks' of the terrestrial planets. But material from the Earth, Mars, comets and various meteorites have Mg/Si and Al/Si ratios, oxygen-isotope ratios, osmium-isoto...

Introduction. Papillary thyroid carcinoma (PTC) is the most common malignancy of the thyroid. An accurate cytological diagnosis is based on distinctive cytological features in combination with immunocytochemistry. Methods. A number of 83 fine needle aspirations, positive for papillary thyroid cancer (44 from thyroid nodules and 39 from cervical lymph nodes), were studied using Thin Layer Cytolo...

the study was undertaken to answer the question that how many patients with pigmentation of back and arms actually have amyloid deposits in pathology. 44 patients presenting with diffuse pigmentation of back and arms (dpoba) were selected. skin biopsies were performed in all cases from the affected sites. on all formalin fixed and paraffin embedded specimens, the following histochemical stains ...