INTRODUCTION Endothelial dysfunction is an early step in the atherosclerotic process and can be quantified by flow-mediated vasodilation (FMD). Our aim was to investigate the effect of long-term rosuvastatin therapy on endothelial function in patients with inflammatory joint diseases (IJD) with established atherosclerosis. Furthermore, to evaluate correlations between change in FMD (ΔFMD) and c...

BACKGROUND The number of studies on the association between clock genes' polymorphisms and cancer susceptibility has increased over the last years but the results are often conflicting and no comprehensive overview and quantitative summary of the evidence in this field is available. RESULTS Literature search identified 27 eligible studies comprising 96756 subjects (cases: 38231) and investiga...

Aurora B helps the central spindle measure up D uring anaphase, cells assemble a central spindle between the segregating chromosomes. Micro-tubule plus ends overlap in the middle of the cell, creating a spindle midzone that recruits factors involved in positioning the cytokinetic actomyosin ring around the cell equator. Regulating the length and organization of central spindle microtubules is t...

Low pH puts proteasomes in storage P eters et al. describe how starving yeast cells regulate the formation of proteasome storage granules (PSGs). The proteasome is a large, multisubunit protease essential for many cellular functions including proliferation. In the absence of glucose or other carbon sources, budding yeast aggregate their proteasomes in PSGs, which may help protect the complexes ...

INTRODUCTION: It is a well known fact that noise annoyance depends on the traffic mode. Much less is known about differences in physiological effects, especially on combined effects. Therefore, we investigated the effects of air (AI), road (RO) and rail (RA) traffic noise on sleep in the AIRORA study. METHODS: 72 subjects (40 ± 13 years, 32 male) were polysomnographically investigated during 11...

Aurora B answers an XIST-ential question E arly in development, mammalian female cells counteract their double dose of X chromosomes by coating one of them with a large RNA named XIST. The RNA binds to the same X chromosome from which it is transcribed and initiates a series of events leading to the chromosome's permanent silencing (1). Hall et al. exploit the fact that XIST temporarily dissoci...

The linear model of Th cell lineage commitment is being revised due to reports that mature Th cells can trans-differentiate into alternate lineages. This ability of Th cells to reprogram is thought to be regulated by epigenetic mechanisms that control expression of transcription factors characteristic of opposing lineages. It is unclear, however, to what extent this new model of Th cell plastic...

Low pH puts proteasomes in storage P eters et al. describe how starving yeast cells regulate the formation of proteasome storage granules (PSGs). The proteasome is a large, multisubunit protease essential for many cellular functions including proliferation. In the absence of glucose or other carbon sources, budding yeast aggregate their proteasomes in PSGs, which may help protect the complexes ...

Adoptive T cell therapy (ACT) is a promising treatment for melanoma patients with a clinical response rate of about 50%. However, half of patients treated do not respond to this therapy, underlining the need for improvement . One of the limitations of ACT is the poor effector function of transferred T cells influenced by the immunosuppressive tumor microenvironment. In order to identify pathway...