Background: Telomeres play a dramatic role in sperm pronuclei formation and subsequently successful fertilization. The H2B family, member W, testis specific (H2BFWT) gene encodes a testis specific histone that colocalized with telomeric sequences and interfere in the dynamic rearrangement of telomeres at late stages of spermatogenesis. H2BFWT is essential for transmission of the telomeric chrom...

Background One kind of sperm abnormality that leads to men infertility is short flagella sperms. In this defect, fibrous sheath and axoneme are disorganized, the sperms tail is short, the numbers of sperms in the semen fluid reduce and the sperms are immotile. There are also other kinds of oligoasthenoteratozospermia (OAT) disorder that causes infertility in men. A kinas anchoring protein 3 (AK...

introduction: embryonic stem (es) cells are pluripotent cells derived from the inner cell mass of blastocysts. these cells are appropriate for creation of animal models of human genetic diseases, the study of gene functions in vivo and differentiation into specific types as potential therapeutic agents for several diseases. we describe here production of transgenic chimeric mouse blastocysts by...

complex chromosomal rearrangements (ccrs) are rare events involving more than two chromosomes and over two breakpoints. they are usually associated with infertility or sub fertility in male carriers. here we report a novel case of a ccr in a 30-year-old oligoasthenosperm man with a history of varicocelectomy, normal testes size and normal endocrinology profile referred for chromosome analysis t...

background: to our knowledge, there is no valid and comprehensive questionnaire that considers attitude toward oocyte donation (od). therefore this study has aimed to design and develop a tool entitled attitude toward donation-oocyte (atod-o) to measure attitude toward od. materials and methods: this methodological, qualitative research was undertaken on 15 infertile cases. in addition, we perf...

introduction cholinergic system is one of the important systems of mammalian cns. cholinergic neurons distributed in brain and spinal cord and contributed to principal functions like: consciousness, learning and memory, and motor control. in this study we investigated the differentiation potentiality of mouse embryonic stem cells toward cholinergic neurons. the aim of this study was to evaluate...

background: infertility is a global public health issue and may adversely affect life satisfaction. one of the most widely instruments used to assess life satisfaction is the satisfaction with life scale (swls). objective: the objective of this study was to examine the psychometric properties of the swls in iranian infertile women. materials and methods: in this descriptive cross-sectional stud...

background: supplementation of luteal phase with progesterone is prescribed for women undergoing routine ivf treatment. objective: the objective of this study was to compare the efficacy of three types of progesterone on biochemical, clinical and ongoing pregnancy rates and abortion and live birth rates. materials and methods: a prospective randomized study was performed at royan institute betw...

a bstract   background: there are a few studies about commissioning mothers’ understanding from the surrogacy during 9 months of waiting for delivery in iran and other countries. this study was conducted with an aim to explore and explain the nature of concerns (experiences) of commissioning mothers. materials and methods:  a qualitative design with a conventional content analysis approach was ...

introduction: the aim of this study was evaluate the ability of notochord to induce neural induction and/or differentiation of mouse embryonic stem cell to neuron and motor neuron, respectively. methods: in order to produce embryoid bodies, es cells line royan b1 were grown in suspension in the absence of lif for 4 days. ebs were divided into 4 groups. ebs in group 1 & 2 were further cultured i...