Hyperhomocysteinemia is associated with endothelial dysfunction, although the underlying mechanism is unknown. Previous studies have shown that nitric oxide (NO) plays an important role in the regulation of systemic and renal hemodynamics. This study investigated whether hyperhomocysteinemia induces renal oxidative stress and promotes renal dysfunction involving disturbances of the NO-pathway i...

BACKGROUND In ischemic acute renal failure (ARF), nitric oxide-dependent regulation of renal hemodynamics and glomerular function is disturbed. Previous studies indicate that the nitric oxide precursor l-arginine (l-Arg) has beneficial effects on renal function. Here we further analyzed the impact of l-Arg on functional and biochemical parameters of nitric oxide signaling during the course of i...

La producción porcina bajo el sistema de cama profunda genera elevados volúmenes desechos. gestión estos residuos a través del compostaje permite su reciclado tras un tratamiento ambientalmente adecuado. Una alternativa uso posterior es la aplicación compost (CCP) suelos dedicados hortícola, los que generalmente presentan estados degradados. El objetivo este trabajo fue evaluar efecto incorpora...

This study examined the effects of different types of calcium channel antagonists on renal haemodynamics and natriuresis. The intravenous infusion of nifedipine (L-type blocker), efonidipine (L/T-type blocker) or mibefradil (predominant T-type blocker) into anaesthetized dogs elicited similar, albeit modest, reductions in blood pressure. Nifedipine (1 microgram.min(-1).kg(-1)) increased renal p...

The present study was performed to determine the effects of neuronal nitric oxide synthase (nNOS) and cyclooxygenase-2 (COX-2) inhibition on blood pressure and renal hemodynamics in transgenic rats with inducible ANG II-dependent malignant hypertension [strain name: TGR(Cyp1a1Ren2)]. Male Cyp1a1-Ren2 rats (n = 7) were fed a normal diet containing indole-3-carbinol (I3C; 0.3%) for 6-9 days to in...

We have previously reported that hyperglycemia in healthy human subjects increased the renal vasodilator response to the angiotensin-converting enzyme inhibitor captopril. This observation raised intriguing possibilities relevant to the pathogenesis of nephropathy in patients with diabetes mellitus. To ascertain whether the effect of captopril was indeed mediated by a reduction in angiotensin I...

Background: Erdheim-Chester disease (ECD) is a multisystemic non-Langerhans cell histiocytosis. Retroperitoneal fibrosis (RPF) common ECD feature, found in up to 60% of patients. Besides ECD, RPF differential diagnosis includes other clinical entities rheumatological interest, such as idiopathic and IgG4-related (IgG4-RD). Since management does not include glucocorticoids mainly relies on the u...

Two important classes of the quantum statistical model, the locally quasi-classical model and the quasi-classical model, are introduced from the estimation theoretical viewpoint, and they are characterized geometrically by the vanishing conditions of the relative phase factor (RPF), implying the close tie between Uhlmann parallel transport and the quantum estimation theory.

Bacillus subtilis yabE encodes a predicted resuscitation-promoting factor/stationary-phase survival (Rpf/Sps) family autolysin. Here, we demonstrate that yabE is negatively regulated by a cis-acting antisense RNA which, in turn, is regulated by two extracytoplasmic function sigma factors: sigma(X) and sigma(M).