The Rockefeller University Press $30.00 J. Cell Biol. Vol. 185 No. 3 409–422 www.jcb.org/cgi/doi/10.1083/jcb.200804038 JCB 409 Correspondence to Paul A. Khavari: [email protected] Abbreviations used in this paper: CA, constitutively active; Erk, extracellular signal-regulated kinase; GO, gene ontology; PI, propidium iodide; Mek, MAPK/ Erk kinase; Rsk, ribosomal S6 kinase; WT, wild type. Intr...

BACKGROUND Protein kinase B (PKB), and the p70 and p90 ribosomal S6 kinases (p70 S6 kinase and p90 Rsk, respectively), are activated by phosphorylation of two residues, one in the 'T-loop' of the kinase domain and, the other, in the hydrophobic motif carboxy terminal to the kinase domain. The 3-phosphoinositide-dependent protein kinase 1 (PDK1) activates many AGC kinases in vitro by phosphoryla...

This research has been conducted on tea grown in the western Mediterranean region and also consumption of Sideritis stricta condensate species, order to investigate their antimicrobial activity against 6 pathogenic bacteria. The plants were collected dried at room temperature flowering stage. essential oil was obtained with a Clevenger apparatus by hydrodistillation method. Antibacterial activi...

Although big mitogen-activated protein kinase 1 (BMK1) has been shown to be critical for embryonic angiogenesis, the role of BMK1 in tumor-associated neovascularization is poorly understood. Exogenous tumors were established in BMK1+/+, BMK1flox/+, or BMK1flox/flox mice carrying the Mx1-Cre transgene. Induced deletion of host BMK1 gene significantly reduced the volumes of B16F10 and LL/2 tumor ...

A matrix M with nonnegative integer entries is minimal if the nonincreasing sequence of its entries (called π-sequence) is minimal, in the dominance order of partitions, among all nonincreasing sequences of entries of matrices with nonnegative integers that have the same 1-marginals as A. The starting point for this work is an identity that relates the number of minimal matrices that have fixed...

Abstract We introduce the R everse S patial Top-k K eyword (RSK) query, which is defined as: given a query term q, an integer k and neighborhood size find all neighborhoods of that where q in top-k most frequent terms among social posts those . An obvious approach would be to partition dataset with uniform grid structure cell identify cells this keywords. However, answer incomplete since it onl...

The effect of the magnetic assisted ball burnishing on a general, C45 steel was investigated considering tribological aspects. In engineering practice, properties machined surfaces are characterized by amplitude roughness parameters from profiles, as Rpk, Rk, Rvk, Rsk and Rku. Information about sliding can be described these together with oil retention capacity surface. Despite conventional pro...