We present a lexical platform t h a t has been developed for the Spanish language. It achieves portabi l i ty between different computer systems and efficiency, in t e rms of lexical coverage. A model for t he full t r e a tmen t of Spanish inflectional morphology for verbs, nouns and adjectives is presented. This model permi t s word formation based solely on morpheme concatenat ion, driven by...

The mouse is a good model for evaluating the efficacy of chemopreventive agents for lung cancer. Gene silencing by promoter hypermethylation is a critical component for the development and progression of lung cancer and an emerging target for preventive intervention by demethylating agents. Genes methylated in mouse lung tumors could serve as biomarkers to evaluate the effectiveness of demethyl...

Current estimates suggest that up to 10% of patients with myeloid neoplasms (MN) harbor variants associated a germline predisposition. A pathogenic variant in the runt-related transcription factor 1 gene (RUNX1) is frequent cause predisposition MN. RUNX1 detected tumor tissue at VAF close 50% are potentially and causative familial platelet disorder malignancies. Previous studies have found 3% a...

Policosanol is known as a hypocholesterolemic compound and derived from plants such sugar cane corn. can lower blood pressure or inhibit adipogenesis, but its effect on osteogenic differentiation the molecular mechanism unclear. This study aims to investigate of policosanol in MC3T3-E1 cells zebrafish models. Administration into induced expression genes distal-less homeobox 5 (Dlx5) runt-relate...

BACKGROUND AND OBJECTIVE Periodontal disease is a common infectious disease, found worldwide, causing the destruction of the periodontium. The periodontium is a complex structure composed of both soft and hard tissues, thus an agent applied to regenerate the periodontium must be able to stimulate periodontal ligament, cementum and alveolar bone regeneration. Recent studies demonstrated that ace...

BACKGROUND Runt-related transcription factor 3 (RUNX3) is a member of the runt-domain family of transcription factors and has been reported to be a candidate tumor suppressor in gastric cancer. However, the association between RUNX3 promoter methylation and gastric cancer remains unclear. METHODS We systematically reviewed studies of RUNX3 promoter methylation and gastric cancer published in ...

Aim: Melatonin promoted osteoblast differentiation and causes an increase in levels of markers bone proliferation. Ramelteon (RAMEL) activates melatonin receptors binds to these as non-selective. In this study, we investigated the preventive effects agonist RAMEL on osteoporosis by radiological, histological, molecularly.Methods: Groups 1: Control, Group 2: Osteoporosis: Overectomized group (OP...