We show that the irregular connection on Gm constructed by Frenkel-Gross ([FG]) and the one constructed by Heinloth-Ngô-Yun ([HNY]) are the same, which confirms the Conjecture 2.14 of [HNY]. The proof is simple, modulo the big machinery of quantization of Hitchin’s integrable systems as developed by Beilinson-Drinfeld ([BD]). The idea is as follows. Let E be the irregular connection on Gm as co...

Supersymmetry (SUSY) between bosons and fermions at the unification-energy scale is one of the most promising hypothesis, which is expecteted to resolve the remaining problems in the standard model. In particular, the minimal supersymmetric extension of the the standard model (MSSM) [1] has been extensively studied in the last decade due to the simplicity. For more than ten years, we have been ...

canaliculi). They present at or shortly after birth, and most cases are associated with other systemic conditions. Uncombable hair syndrome is similar to APKH; however, the SEM cross-section appears triangular, which is different from the presentation of APKH. Diffuse partial woolly hair (DPWH) and environmental factors such as trauma, radiation and drugs should also be ruled out. DPWH comprise...

Two S-adenosyl-L-methionine:furanocoumarin O-methyltransferases of R. graveolens, acting at the 5- and 8-hydroxyl of the psoralen nucleus, were completely resolved by adsorption on a general affinity ligand, 5-(3-carboxypropanamido) xanthotoxin, followed by specific desorption by bergaptol and xanthotoxol, respectively. The 5-O-methyltransferase was purified 450-fold by this procedure, the 8-O-...

Alexander L. Greninger, M.D., Ph.D., Samia N. Naccache, Ph.D., Kevin 4! Messacar, M.D., Anna Clayton, B.S., M.P.H., Guixia Yu, B.S., Sneha Somasekar, 5! B.S., Scot Federman, B.A., Doug Stryke, B.S., Christopher Anderson, B.S, 6! Shigeo Yagi, Ph.D., Sharon Messenger, Ph.D. , Debra Wadford, Ph.D. , Dongxiang 7! Xia, M.D., Ph.D., James P. Watt, M.D., M.P.H. , Keith Van Haren, M.D., Samuel R. 8! Do...

BACKGROUND Apium graveolens L. is a traditional Chinese medicine prescribed as a treatment for hypertension, gout, and diabetes. This study aimed to determine the neuroprotective effects of A. graveolens extract against a Parkinson's disease (PD) model induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in C57BL/6 mice. METHODS Male C57BL/6 mice treated with MPTP were orally dosed ...