Co-administration of piperine, an alkaloid isolated from Piper nigrum L. enhanced bioavailability of beta lactam antibiotics, amoxycillin trihydrate and cefotaxime sodium significantly in rats. The improved bioavailability is reflected in various pharmacokinetic parameters viz. tmax, Cmax, t(1/2) and AUC, of these antibiotics. The increased bioavailability could be attributed to the effect of p...

In anaerobic soil disinfestation (ASD), amended with a carbon source undergoes conditions accompanied by changes in microbial community composition and an increase the concentration of organic acids, primarily acetic butyric gases that are deleterious to plant pathogens, insects, potentially weeds. The purpose this study was explore efficacy ASD different sources on inactivation propagules vari...

Abstract. Amanah S, Budiastuti MTHS, Sulistyo A. 2022. Effect of the media type and auxin concentration on growth cuttings seedlings pepper (Piper nigrum). Cell Biol Dev 6: 32-40. Pepper nigrum L.) is an export commodity has become one Indonesian sources income. It necessary to develop best cultivation for increasing production. Vegetative propagation been chosen in this research, using manure ...

Background: Pepper plants belong to the Piperaceae family with many pharmacological activities. The fruits of these have been widely used traditionally for various therapies, one which is an aphrodisiac. Objective: purpose this study was determine aphrodisiac activity three pepper plants, Piper nigrum, retrofractum, and cubeba prove their traditional use. Methods: level piperin, active compound...

Ampicillin and Norfloxacin are used to treat variety of bacterial infections. These two drugs have low oral bioavailability. Co-administration of Piperine (20 mg/kg), an alkaloid from Piper nigrum L. enhanced oral bioavailability of Ampicillin and Norfloxacin in animal model. This is reflected in various pharmacokinetic measurements like Cmax, Tmax, AUC and t(1/2) of the above antibiotics in an...

Large areas of soils have been contaminated by heavy metals, which are deleterious to the existence, reproduction and development of living organisms including plants, animals and microorganisms. The contamination of nature compartments by heavy metals has become a serious environmental problem. Due to the high cost of conventional clean-up technologies, there is an increasing interest in the r...

Piper nigrum (P. nigrum) is commonly used in traditional medicine. This current study aimed to investigate the anticancer and cancer preventive activity of a piperine-free P. nigrum extract (PFPE) against breast cancer cells and N-nitrosomethylurea (NMU)-induced mammary tumorigenesis in rats. The cytotoxic effects and the mechanism of action were investigated in breast cancer cells using the MT...

Four sourdoughs (A to D) were produced under practical conditions, using a starter obtained from a mixture of three commercially available sourdough starters and baker's yeast. The doughs were continuously propagated until the composition of the microbiota remained stable. A fungi-specific PCR-denaturing gradient gel electrophoresis (DGGE) system was established to monitor the development of th...

introduction heavy metals are largely found in dispersed form in rock formations. industrialization and urbanization have increased the anthropogenic contribution of heavy metals in the biosphere. heavy metal pollution not only affects the production and the quality of crops, but also influences the quality of the atmosphere and water bodies, and threatens the health and life of human beings. c...