Antimicrobial substances, including antibiotics such as polymyxin and novobiocin, detergents, and complement, all of which are known or presumed to have an effect upon membrane permeability, showed greater potency against ethylenediaminetetraacetic acid (EDTA)-treated Salmonella typhi than against untreated cells of that organism. The differential effect was particularly marked with the complem...

Non-typhoidal Salmonella are infrequent causes of childhood meningitis. Most reports of Salmonella typhi meningeal infections are confined to neonates. A rare instance of S. typhi in an otherwise healthy eleven month old infant is being reported.

Typhoid fever caused by Salmonella enterica serovar typhi (S. enterica serovar typhi) is one of the important public health problems in many developing countries. Conventional blood culture is currently the gold standard for diagnosis of typhoid fever by this bacterium, but it is time-consuming requiring several days for isolation of bacterium resulting in delay to initiate proper antibiotic th...

A 2-year study of systemic and intestinal immunity to Salmonella typhi was performed in 14 patients who were suffering from typhoid fever in an attempt to extrapolate the mechanism of immune responses in this disease. The methods employed were the leukocyte migration inhibition agarose test for the measurement of systemic cell-mediated immunity. The systemic immunoglobulin G (IgG) and IgM that ...

A study of genotyping (pulsotyping) of Salmonella typhi (S. typhi) isolates using pulse-field gel electrophoresis (PFGE) methods was performed to examine their genetic diversity, and relationship between genetic characteristics and clinical outcomes. Sixty-six S. typhi isolates obtained from sporadic hospitalized typhoid fever cases were used in this study. Four isolates were found identical an...

Vaccines against Salmonella Typhi, the causative agent of typhoid fever, are commonly used by travellers, however, there are few examples of national immunization programs in endemic areas. There is therefore a paucity of data on the impact of typhoid immunization programs on localised populations of S. Typhi. Here we have used whole genome sequencing (WGS) to characterise 44 historical bacteri...

BACKGROUND Typhoid fever remains a worldwide problem, but it is particularly common in Southeast Asia, including Indonesia. The causative agent Salmonella Typhi is known to have significant genome plasticity. METHODOLOGY This study describes genetic fingerprints using restriction fragment length polymorphism with SpeI of chromosomal DNA and pulsed-field gel electrophoresis (PFGE) of S. Typhi ...

Blood culture isolates of Salmonella enterica serovar Typhi showing high degrees of resistance to ampicillin, chloramphenicol, cotrimoxazole and tetracycline (ACCoT-resistance) transferred their full resistance phenotype to antibiotic-sensitive S. enterica serovar Typhi strains through the primary recipient Escherichia coli C600. Transfer frequencies were 0.80 x 10(-5) and 0.80 x 10(-6), respec...

BACKGROUND This study examined the susceptibility of Gram-negative bacteria in the bloodstream to antimicrobials with the aim of providing information relevant to the guidance of therapy. METHODOLOGY Blood specimens received by the Laboratory of Clinical Microbiology, Faculty of Medicine, University of Indonesia, from 2002 to 2008, were analyzed for the presence of Gram-negative bacteria and ...

OBJECTIVES Typhoid fever is a dreadful disease of a major threat to public health in developing countries. Vaccination with bacterial immunodominant components such as surface proteins may prove as a potent alternative to live attenuated vaccines. InvH, an important part of needle complex in type three secretion system (TTSS) plays important role in efficient bacterial adherence and entry into ...