Leptospirosis is a worldwide zoonosis caused by pathogenic Leptospira. The whole-genome sequence of L. interrogans serovar Copenhageni together with bioinformatics tools represent a great opportunity to search for novel antigen candidates that could be used as subunit vaccine against leptospirosis. We focused on six genes encoding for conserved hypothetical proteins predicted to be exported to ...

Intracellular delivery of functional macromolecules using peptide transduction domains (PTDs) is an exciting technology with both experimental and therapeutic applications. Recent data indicate that PTD-mediated transduction occurs via fluid-phase macropinocytosis involving an intracellular pH drop to approximately 5. Nitrilotriacetic acid (NTA)-coordinated metals avidly bind hexahistidine-tagg...

Patient 1 showed onset at the age of 28 with facial and limb dystonia, pyramidal signs, and cerebellar ataxia as well as bulging eyes and ophthalmoplegia. His father was 63 at disease onset and his mother 65. Moreover, their clinical manifestations were very mild compared with those of the sonnamely, mild cerebellar signs and mild to moderate peripheral nerve involvement without bulging eyes. C...

BACKGROUND Achalasia is a rare disease with a morbidity of 1 in 100,000, for which the exact mechanism of pathogenesis has not been clarified due to the small total number of patients. We herein report on our experience with two cases of familial achalasia in which the involvement of genetic inheritance was suspected. CASE PRESENTATION These cases consist of a man in his thirties and his moth...

The Laius complex is the father's complex of fear of the son as a potential rival in his own prerogatives. I t is considered more fundamental than the Freudian Oedipus complex which describes the son's rivalry with his father, founded on the son's sexual desire for his mother. Laius is the father of Oedipus. Graber3 holds that the original guilt rests with Laius (12, p. 17f.). Since Laius wante...

A 67-year-old married, unemployed, primary school-educated (5 years of education) female was born as one of identical twin sisters. The patient did not have any complaints when she was brought to our psychiatry clinic by her son in June 2013; however, her son reported that his mother believed that she could see her identical twin sister in the mirror, and that her identical twin was trapped in ...

In October 1936 I was consulted regarding the painful condition of the thigh of the son of a government servant in the employ of the Military Engineering Service. For over six months the boy had been complaining of increasing pain and difficulty in the right thigh on walking. The father thought that his son had always been weak on the right leg, but that recently the boy had been quite lame, an...

Byungchul Cha ([email protected]) teaches at Muhlenberg College in Allentown, Pennsylvania, after working for three years at Hendrix College. He received his B.S. from the Korea Advanced Institute of Science and Technology, and his Ph.D. from Johns Hopkins University. His area of specialization is number theory. When he is not teaching calculus, he enjoys engaging his young son in doing other ...

A 55 year old driver left after Fajr prayer to the vegetable market to buy a few things for his daughter’s wedding lunch. While trying to avoid a big pothole in the middle of the road, he was hit by a truck without headlights coming from the opposite direction. The truck driver continued driving as if nothing had happened. None of the road users cared to help the victim but he was able to conta...