Ciobica Alin »Alexandru Ioan Cuza« University Dept. of Biology B dul Carol I, 11 700506, Iasi, Romania Tel :0040751218264; Fax 0040232201472 e-mail: alin.ciobicaauaic.ro Summary: It has already been demonstrated that a complete brain renin–angiotensin system (RAS) exists distinctly separate from the peripheral system and is implicated in complex functions such as memory, emotional responses and...

BACKGROUND Moxifloxacin, a fluoroquinolone antibiotic, is used for the treatment of respiratory tract, pelvic inflammatory disease, skin, and intra-abdominal infections. Its safety profile is considered favorable in most reviews but has been challenged with respect to rare but potentially fatal toxicities (e.g. hepatic, cardiac, or skin reactions). OBJECTIVE To analyze and compare the safety ...

Background Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is a rare hereditary autoinflammatory disease characterized by fever as well severe systemic and organ inflammation. Successful treatment was achieved with the interleukin-1β inhibitor canakinumab (CAN) in pivotal phase 3 study, which 45% of patients reached clinical remission after 16 weeks (primary endpoint) 1 . CA...

architecture has been always recognized as a framework which is influenced by social beliefs, traditions and interactions and furthermore affects individual soul and tendency. therefore it is impossible to analyze and consequently identify an architectural artifact if not accompanied by analysis of intellectual fundamentals of its contemporary society. the ensemble of sheikh safi al-din which i...

166 11 JULY 2014 • VOL 345 ISSUE 6193 S ince 2001, HIV incidence has declined by 33% worldwide, and more than 9.7 million people with HIV have gained access to treatment.* The Joint United Nations Programme on HIV/ AIDS launched the Getting to Zero strategy (2011–2015) that includes zero new infections, zero deaths from HIV, and zero discrimination. Aspirational statements such as “the end of A...

This Article is concerned with one key aspect of the law of the military jihad: the Islamic concept of martyrdom [shahada or istishhad]. This Article will demonstrate that the current Islamist financing and systematic organization and direction of self-annihilatory acts of violence is only weakly supported, if at all, by the classical sources on martyrdom in Islamic law and jurisprudence. The A...

We introduce the use of quantum dot (QD) nanoparticles for near-surface velocimetry and provide preliminary data to demonstrate its feasibility. Evanescent wave illumination is used to image the motion of water-soluble (CdSe)ZnS QDs with a core size of 6 nm within a region of order 100 nm of a surface . Results are presented for the two in-plane components of the velocity field. With the recent...

This dissertation presents new signaling schemes and circuit architectures for reducing the power and cost of high-speed chip-to-chip links. After an overview on chip-to-chip interconnects and its building blocks, a new signaling scheme is proposed that can provide many advantages of a fully-differential signaling scheme while employing as few as N + 1 signal paths for communicating N different...

166 11 JULY 2014 • VOL 345 ISSUE 6193 S ince 2001, HIV incidence has declined by 33% worldwide, and more than 9.7 million people with HIV have gained access to treatment.* The Joint United Nations Programme on HIV/ AIDS launched the Getting to Zero strategy (2011–2015) that includes zero new infections, zero deaths from HIV, and zero discrimination. Aspirational statements such as “the end of A...