AIM To propose a relevant grading scale for clinical adverse events or laboratory results, electrocardiogram (ECG) and vital sign findings supporting both dose escalation and stopping decisions in first-entry-into-man (FIM) studies conducted in young healthy subjects. METHODS A three-level scale was used for the proposed grading system. The grading is directly derived from the observed severi...

Researches using existing statistics and data collected from the area of study help officials at decision-making, to improve the region's problems, like the problem of the high rate of accidents in the region, despite the low volume of daily service. The uses of roundabouts in many parts of the world have many advantages over intersections, amongst them are increased safety and capacity and red...

how to cite this article: karimzadeh p. juvenile type of niemann-pick type c disease and our study in iranian npc patients. iran j child neurol. 201 5 autumn;9:4(suppl.1): 5-6. pls see pdf.

Preliminary work on the development of measures appropriate for the safety domain is reported. Measures are expressed in the style of the Practical Software and Systems Measurement (PSM) approach, a programme sponsored by the US DoD. Proposed measures are integrated with the PSM measurement framework. Reported work has been informed by discussions within the PSM community and by concurrent work...

This paper lays out the components of a language acquisition model, the interconnections among the components, and the differing stances of nativism and empiricism about syntax. After demonstrating that parsimony cannot decide between the two stances, the paper analyzes nine examples of evidence that have been used to argue for or against nativism, concluding that most pieces of evidence are ei...

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Für Benutzer ist es im Allgemeinen nicht möglich, für jeden Dienst ein unabhängiges, starkes Passwort zu wählen. Diese Situation legt es nahe, den Nutzern ein Single Sign-on (SSO) anzubieten, das es erlaubt, sich mit nur noch einem Passwort an mehreren Diensten anzumelden. Pseudo-SSO-Systeme müssen nicht vom Dienstanbieter unterstütz werden, und sind daher für den Nutzer sofort nützlich, bei ih...

The purpose of this study was to determine the nature and efficiency of the strategies used by prelingually deafened native signers for the temporary retention of written words with reference to a primary language-coding hypothesis (M. A. Shand, 1982). For the gathering of the data, participants were shown lists of serially presented written target words that they were asked to recognize accord...

Due to the aging U.S. highway system and the frequent presence of work zones, highway work zone safety is garnering increasing attention. Police enforcement is sometimes used by U.S. transportation agencies for safety improvement in work zones. The important question that must be answered by those responsible for programming police enforcement in work zones is: where, when and how to enforce? T...