PURPOSE The purpose of this study was to determine therapeutic effect of a novel antibiotic, reveromycin A, against osteolytic bone metastasis of human small cell lung cancer (SBC-5) cells. RESULTS Reveromycin A induced apoptosis specifically in osteoclasts in vitro. Although reveromycin A did not inhibit SBC-5 cell proliferation, it suppressed the expression of parathyroid hormone-related pe...

BACKGROUND Little information is available about the association between bronchomalacia and historical or clinicopathologic data. Also, studies applying an endoscopic classification scheme that differentiates between static and dynamic bronchial collapse and based on a scoring system are lacking. OBJECTIVES To describe the clinical presentation of bronchomalacia in dogs, to classify endoscopi...

The simple Bayesian classi er (SBC), sometimes called Naive-Bayes, is built based on a conditional independence model of each attribute given the class. The model was previously shown to be surprisingly robust to obvious violations of this independence assumption, yielding accurate classi cation models even when there are clear conditional dependencies. We examine di erent approaches for handli...

PURPOSE The purpose of this study was to determine whether angiogenesis, as measured by microvessel density (MVD), at presentation is related to subsequent progression of superficial bladder cancer (SBC). EXPERIMENTAL DESIGN Archived primary bladder tumors from 180 patients were stained with a monoclonal antibody against cluster determinant 34 to label vessels. Image analysis was used to coun...

The minimum k-partition (MkP) problem is the problem of partitioning the set of vertices of a graph into k disjoint subsets so as to minimize the total weight of the edges joining vertices in the same partition. The main contribution of this paper is the design and implementation of a branch-and-cut algorithm based on semidefinite programming (SBC) for the MkP problem. The two key ingredients f...

The common search for a Pareto-optimal set, and the associated front, usually serves as a preprocessing stage for a Multi-Criteria Decision Making (MCDM). In that case the optimization provides information to support the selection of a final solution from a feasible space of solutions. Here, we are interested in a rather different MCDM problem and its associated preprocessing stage. Our study c...

To examine whether discordance in the hormone-receptor status predicts clinical outcomes in patients with bilateral synchronous (SBC) or metachronous breast cancer (MBC), we analyzed data from the Surveillance, Epidemiology, and End Results program (1998-2011) using Cox models. After excluding 10,231 patients with missing data on hormone receptors in at least one tumor, 4403 SBC and 7159 MBC we...

A three-dimensional mathematical model was developed to examine the transient and steady-state temperature distribution in the human brain during selective brain cooling (SBC) by unilateral intracarotid freezing-cold saline infusion. To determine the combined effect of hemodilution and hypothermia from the cold saline infusion, data from studies investigating the effect of these two parameters ...

Modified oligodeoxyribonucleotides (ODNs) that have unique hybridization properties were designed and synthesized for the first time. These ODNs, called selective binding complementary ODNs (SBC ODNs), are unable to form stable hybrids with each other, yet are able to form stable, sequence specific hybrids with complementary unmodified strands of nucleic acid. To make SBC ODNs, deoxyguanosine (...

The spinocerebellar systems are essential for the brain in the performance of coordinated movements, but our knowledge about the spinocerebellar interactions is very limited. Recently, several crucial pieces of information have been acquired for the spinal border cell (SBC) component of the ventral spinocerebellar tract (VSCT), as well as the effects of SBC mossy fiber activation in granule cel...