A domestic multicenter phase I study of stereotactic body radiotherapy (SBRT) for T2N0M0 non-small cell lung cancer in inoperable patients or elderly patients who refused surgery was initiated as the Japan Clinical Oncology Group trial (JCOG0702) in Japan. Prior to the clinical study, the accuracy of dose calculation in radiation treatment-planning systems was surveyed in participating institut...

Ipilumimab, which is a monoclonal antibody to the inhibitory T-cell receptor CTLA-4, has been shown to improve survival in patients with metastatic melanoma; however, the response rate was only 10%, necessitating the need to develop ways to improve treatment. Anecdotal evidence suggests that stereotactic body radiation (SBRT) might cooperate with anti-CTLA4 to improve response rates both for ir...

PURPOSE Several mathematical models exist to predict secondary cancer risks from radiotherapy treatment. In this study, we aimed to compare three dosimetry-based models in the application of stereotactic body radiotherapy (SBRT) of early-stage non-small cell lung cancer (NSCLC) with three radiotherapy treatment modalities. METHODS Ten patients who received definitive SBRT for early-stage NSCL...

PURPOSE Locally recurrent non-small cell lung cancer (LR-NSCLC) remains challenging to treat, particularly in patients having received prior radiotherapy. Heterogeneous populations and varied treatment intent in existing literature result in significant limitations in evaluating efficacy of lung re-irradiation. In order to better establish the impact of re-irradiation in patients with LR-NSCLC ...

Objective: To observe the efficacy and safety of stereotactic body radiotherapy (SBRT) in treatment extracranial oligometastases. Method: A retrospective analysis 70 patients with oligometastasis malignant tumors who underwent SBRT our hospital (Shaanxi Provincial People’s Hospital) from January 2019 to December 2021 ? 5 metastases, ?3 metastatic organs, metastases diameters cm. According clini...

BACKGROUND Even with early stage hepatocellular carcinoma (HCC), patients are often ineligible for surgical resection, transplantation, or local ablation due to advanced cirrhosis, donor shortage, or difficult location. Stereotactic body radiation therapy (SBRT) has been established as a standard treatment option for patients with stage I lung cancer, who are not eligible for surgery, and may b...

The purpose of this study was to assess target repositional accuracy with respect to the bony structures using daily CBCT, and to validate the planning target volume (PTV) margin used in the lung SBRT. All patients underwent 4D CT scanning in preparation for lung SBRT. The internal target volume (ITV) was outlined from the reconstructed 4D data using the maximum-intensity projection (MIP) algor...

PurposeThe immunocytokine L19-IL2 delivers interleukin-2 to the tumor by exploiting selective L19-dependent binding of extradomain B fibronectin on blood vessels. In preclinical models, has been shown enhance local and abscopal effects radiation therapy. The clinical safety monotherapy established previously. this study, tolerability after stereotactic body therapy (SBRT) was assessed.Methods M...