Recent data from the cognitive and behavioral sciences suggest that irrelevant features of our environment can often play a role in shaping our morally significant decisions. This isn’t always a bad thing. But our inability to suppress or moderate our reflexive reactions can lead us to behave in ways that diverge from our reflectively held ideals, and to pursue worse options while knowing there...

Scientists often use models to help develop theories and plan experiments. Computational tools have greatly expanded the sophistication of such models. One such tool, the Oncology Thinking Cap (OncoTCap) provides a comprehensive modeling workbench for cancer researchers. This tool is versatile and can be used to model clinical trials, but its functions and operation may impose excessive cogniti...

Challenge studies following passive immunization with neutralizing Abs suggest that an HIV vaccine could be efficacious were it able to elicit broadly neutralizing Abs (bNAbs). To better understand the requirements for activation of B cells producing bNAbs, we generated cell lines expressing bNAbs or their germline-reverted versions (gl-bNAbs) as BCRs. We then tested the abilities of the bNAb-e...

Somatic mosaicism refers to the existence of somatic mutations in a fraction of somatic cells in a single biological sample. Its importance has mainly been discussed in theory although experimental work has started to emerge linking somatic mosaicism to disease diagnosis. Through novel statistical modeling of paired-end DNA-sequencing data using blood-derived DNA from healthy donors as well as ...

INTRODUCTION With all of the developments on infectious diseases, tuberculosis (TB) remains a cause of death among people. One of the most promising assembly techniques in nano-technology is "scaffolded DNA origami" to design and construct a nano-scale drug delivery system. Because of the global health problems of tuberculosis, the development of potent new anti-tuberculosis drug delivery syste...

It has been proposed that enzymes can associate into complexes (metabolons) that increase the efficiency of metabolic pathways by channelling substrates between enzymes. Metabolons may increase flux by increasing the local concentration of intermediates, decreasing the concentration of enzymes needed to maintain a given flux, directing the products of a pathway to a specific subcellular locatio...

P roponents of bioresorbable scaffolds (BRS) define them as a transformative technology suggesting that coronary repair will improve long-term clinical outcomes. Skeptics have questioned the early safety, and overall merit of BRS in the era of secondand third-generation drug-eluting metallic stents (DES). Nevertheless, BRS have sparked enormous interest and debate. Indeed, over the last decade ...

Programmed self-assembly of DNA enables the rational design of megadalton-scale macromolecular assemblies with sub-nanometer scale precision. These assemblies can be programmed to serve as structural scaffolds for secondary chromophore molecules with light-harvesting properties. Like in natural systems, the local and global spatial organization of these synthetic scaffolded chromophore systems ...