OBJECTIVE To examine the impact of sickle cell disease (SCD) on academic attainment; the relation between academic attainment and achievement in SCD; and determinants of attainment in SCD. METHODS Children with SCD and demographically matched peers were compared on academic attainment. Hematocrit, illness frequency, cognitive ability, and socioeconomic status were used to model the predictors...

‘Sickle hepatopathy’ is a condition which seen in only 10% cases of sickle cell disease (SCD). Sickle hepatopathy could be due to acute crisis, sequestration, cholangiopathy, severe intrahepatic cholestasis or as result chronic blood transfusion related infection and hemosiderosis. Differentiating the cause for SCD challenging. Hepatopathy manifestation can range from mild liver function test a...

Sudden cardiac death (SCD) is a devastating complication of many forms of heart disease and on occasion presents in the absence of structural cardiac abnormalities. SCD caused by ventricular arrhythmias is a daunting public health problem with 200 000 to 450 000 events in the United States annually. 1 There are many challenges in the definition, mechanisms, and management of SCD that will be ad...

Fatty acid desaturases such as steaoryl-CoA desaturase (SCD) convert saturated to unsaturated fatty acids and are involved in lipogenesis. Observational and animal data suggest that SCD-1 activity is related to insulin sensitivity. However, the effects of insulin-sensitizing drugs on SCD gene expression and desaturase activities are unknown in humans. In a randomized, placebo-controlled, double...

Sickle cell disease (SCD) pain continues to emerge in adolescents. More than 98,000 individuals are believed to have SCD in the United States. In fact, 1 in 500 Black infants will be affected by SCD. Identifying standards of care for this unique population can improve pain management and treatment. A significant effect of vaso-occlusive crisis is a decrease in the quality of life in children. T...

PURPOSE Sickle cell disease (SCD) subjects have been widely reported to present with various anthropometric deficits, including malocclusion and stunting, compared to their unaffected peers. This study was carried out to examine these reports in Lagos. METHODS A hospital-based cross-sectional study was carried out in 3 outpatient SCD units of one teaching and two general hospitals. All establ...

Stearoyl-coenzyme A desaturase (SCD) catalyzes the Δ9-cis desaturation of saturated fatty acids (SFA) to generate monounsaturated fatty acids (MUFA). This enzyme is highly up-regulated by platelet-derived growth factor (PDGF) in human fibroblasts. Accordingly, the analysis of cellular fatty acids by gas chromatography showed that PDGF significantly increased the proportion of MUFA, particularly...

OBJECTIVES We assessed the relationship of season and weather types with myocardial infarction (MI) and sudden cardiac death (SCD) in a geographically defined population, and tested the hypothesis that the increased risk in winter was related to weather. BACKGROUND Winter peaks in coronary heart disease (CHD) have been documented. Yet, it is uncertain if seasonality exists for both incident e...

Among access control models, Role-Based Access Control (RBAC) is very useful and is used in many computer systems. Static Combination of Duty (SCD) and Dynamic Combination of Duty (DCD) constraints have been introduced recently for this model to handle dependent roles. These roles must be used together and can be considered as a contrary point of conflicting roles. In this paper, we propose sev...