BACKGROUND Despite limited evidence, woollen clothing has traditionally been considered to be an irritant that should be avoided by individuals with atopic dermatitis (AD). Wool fibres come in a range of diameters, and have beneficial thermodynamic and moisture transport properties. OBJECTIVES This study examines the effects of superfine merino wool on symptoms in participants with mild-to-mo...

Irritation of the skin of patients with atopic dermatitis by contact with rough fibres of synthetic or woollen clothes is well known. Therefore, it has been recommended that patients should wear cotton clothes. However, cotton also consists of rough fibres able to irritate the skin, whereas silk is characterized by smooth fibres without irritating potential. The aim of our study was to evaluate...

BACKGROUND Recent data suggested that imbalance in gut microbiota and gastrointestinal inflammation are associated with the childhood allergic disease. Fecal calprotectin has been used for a non-invasive marker of gut inflammation. OBJECTIVE The aim of this study was to investigate the relationships between fecal calprotectin level and the clinical severity of atopic dermatitis (AD) in childr...

The role of a genetically impaired epidermal barrier as a major predisposing factor in the pathogenesis of atopic disorders is currently under closer investigation. Vari­ ants on three candidate genes (SPINK5, KLK7 and FLG) have been associated with atopic dermatitis. A functional relevance has already been established for filaggrin vari­ ants, but not for SPINK5 and KLK7 polymorphisms. The obj...

BACKGROUND Over the last two decades the incidence of allergic diseases has increased in industrialized countries, and consequently new approaches have to be explored. OBJECTIVE The potential of probiotics to control allergic inflammation at an early age was assessed in a randomized double-blind placebo-controlled study. METHODS A total of 27 infants, mean age 4.6 months, who manifested ato...

269 Refractory Chronic Urticaria Treated with Omalizumab Martinez Saenz, NP, Ramírez Del Pozo, ME, Lopez Tiro JJ, and Javier Gomez Vera, MD. Alergia e inmunologia clínica, Hospital Regional Lic. Adolfo Lopez Mateos, Distrito Federal, Mexico. Background: Chronic urticaria (CU) is a common disorder characterized by recurrent episodes of urticaria pruritic erythematous lesions, associated with ang...

RATIONALE In mouse models for atopic dermatitis (AD) hypothalamus pituitary adrenal axis (HPA) dysfunction and neuropeptide-dependent neurogenic inflammation explain stress-aggravated flares to some extent. Lately, cholinergic signaling has emerged as a link between innate and adaptive immunity as well as stress responses in chronic inflammatory diseases. Here we aim to determine in humans the ...

Background: Studies suggest that low concentrations of n–6 long-chain polyenes in early life are correlated to atopic disease in later life. Objective: The purpose of the study was to investigate the possible preventive effect of -linolenic acid (GLA) supplementation on the development of atopic dermatitis in infants at risk. Design: In a double-blind, randomized, placebo-controlled trial, form...

© Copyright The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease http://e-aair.org Atopic dermatitis (AD) is a chronically recurrent inflammatory skin disorder characterized by pruritus, a specific distribution, and a family history. It has recently been reported that the incidence of AD has increased in Korea. Pruritus,...