OBJECTIVE To see if Metformin Monotherapy affects glycemic control, serum lipid or lipoprotein levels in the treatment of type 2 diabetes who were poorly controlled with diet alone or despite maximal doses of (sulfonylurea) oral glucose lowering agents. DESIGN A prospective, clinical intervention trial conducted between 1996-1997. SETTING Two out patient diabetic clinics of Karachi. PATIE...

Placental transfer of the HIV protease inhibitor darunavir was investigated in 5 term human cotyledons perfused with darunavir (1,000 ng/ml) in the maternal to fetal direction. The mean (± the standard deviation [SD]) fetal transfer rate (FTR) (fetal/maternal concentration at steady state from 30 to 90 min) was 15.0%±2.1%, and the mean (±SD) clearance index (darunavir FTR/antipyrine FTR) was 40...

BACKGROUND Pre-eclampsia and placental causes of intrauterine growth restriction (IUGR) are part of the same spectrum of disorders. In IUGR, there is preferential shunting of blood to the fetal brain at the expense of other organs. We wanted to demonstrate that this also occurs in pre-eclampsia using three dimensional (3D) ultrasound. The 3D indices of perfusion are: flow index (FI), vascular i...

We compute the Fadell-Husseini index of the dihedral group D8 = (Z2)2 ⋊ Z2 on S × S, that is, the kernel of the map in equivariant cohomology H ∗ D8 (pt,F2) −→ H ∗ D8 (Sd × Sd,F2). This establishes the complete cohomological lower bound for the two hyperplane case of Grünbaum’s 1960 mass partition problem: For which d and j can two hyperplanes be found that cut j arbitrary measures on R into fo...

AIM To demonstrate the effectiveness of a digital radiographic altering technique in concealing treatment allocation to blind outcome assessment of distal femur fracture fixation. METHODS Digital postoperative anteroposterior and lateral radiographs from a sample of 33 randomly-selected patients with extra-articular distal femur fractures treated by surgical fixation at a Level 1 trauma cente...

objective: the present study aimed to review the relapse rate in patients with schizophrenia treated with orally taken atypical agents (serotonin dopamine antagonists, sdas) and depot preparation of conventional (typical) antipsychotics. methods: in this historical cohort study, mean relapse per month (mrm) index, duration between initiation of antipsychotic treatment and the first relapse epis...

OBJECTIVES The objectives of this study included: (1) evaluation of the Polish version of Mother Generated-Index (MGI) as a tool for measuring antenatal Health Related Quality of Life (HRQL) of hospitalized women; (2) identification of factors influencing antenatal quality of life of hospitalized women; (3) assessment of correlations between MGI and SF-36v2, and between MGI and EQ-5D. MATERIA...

UNLABELLED Oral hygiene is an important etiological factor related to oral health status in children. The aim of the study was to evaluate the oral hygiene status in children with type I diabetes mellitus (DM) and in their non-diabetic controls, and to correlate it with the health condition of the gingival tissues. MATERIALS AND METHODS Seventy 10-15 year-old children (mean age 13.6, SD=1.6) ...