We analyzed the responses of several T cell fractions reactive with superantigenic toxins (SAGTs), staphylococcal enterotoxin A (SEA), or Yersinia pseudotuberculosis-derived mitogen (YPM) in mice implanted with mini-osmotic pumps filled with SEA or YPM. In mice implanted with the SEA pump, SEA-reactive Vbeta3(+)CD4(+) T cells exhibited a high-level protracted expansion for 30 days, and SEA-reac...

Arctic amplification of global warming has led to increased summer sea ice retreat, which influences gas exchange between the Arctic Ocean and the atmosphere where sea ice previously acted as a physical barrier. Indeed, recently observed enhanced atmospheric methane concentrations in Arctic regions with fractional sea-ice cover point to unexpected feedbacks in cycling of methane. We report on m...

The superantigen staphylococcal enterotoxin A (SEA) requires interaction with class II major histocompatibility complex (MHC) molecules to activate T cells. We have previously used the synthetic peptide approach to establish one side of the hypothetical class II foreign-antigen binding cleft, alpha-helical region 65-85 of the beta chain, as a binding site involved in accessory cell presentation...

[1] The Sulu Sea, isolated from the neighboring ocean below 570 m, is nearly isothermal below 1250 m but with a marked salinity increase with depth. The source of the deep Sulu Sea water has been attributed to South China Sea water overflowing the 570 m topographic sill of Panay Strait. However, the Panay overflow (estimated as 0.32 × 10 m/sec) is an unlikely source for the saltier water Sulu S...

BACKGROUND Behavioural variant of frontotemporal dementia (bvFTD) is a neurodegenerative disease that is clinically characterised by progressive behavioural changes and social interpersonal dysfunctions. Its diagnosis remains a clinical challenge, and depression is one of the main causes of misdiagnoses due to the prevalence of apathy in bvFTD. OBJECTIVE To evaluate the sensitivity and specif...

To examine the ability of dendritic cells (DC) to discriminate between helminth and microbial Ag and induce appropriately polarized Th responses, mouse DC were copulsed with the helminth Ag, schistosome egg Ag (SEA), along with the bacterium Proprionebacterium acnes, Pa, and transferred into wild-type mice. Strikingly, SEA/Pa-copulsed DC induced concurrent Pa-specific Th1 (but not Th2) response...

background: marine natural products contain a wide range of bioactive compounds with therapeutic properties that have revealed crucial properties in the treatment of some diseases. some of these compounds have recently received considerable attention for drug discovery. in this study we examined the anti-angiogenic effect of saponin isolated from holothuria leucospilota (sea cucumber) through e...

the systematics, morphology, distribution, biology, economic importance and conservation of the lamprey of iran are described, the species is illustrated, and a bibliography on this fish in iran is provided. there is one native and endemic species in the caspian sea basin, caspiomyzon wagneri . the genus caspiomyzon is characterised by having 2 dorsal fins, an oral disc narrower than the body, ...

sturgeons are the most important fish in the caspian sea, but there are only a few reports on their parasite communities in the southern part of this sea. in this study, a total of 93 individuals of four sturgeon species, namely acipenser stellatus (n= 60), a.gueldenstaedtii (n = 12), a. nudiventris (n = 9) and huso huso (n = 12), were caught in 2 geographical regions from the southwest of the ...

Sea clutter refers to the backscattered returns from a patch of the sea surface illuminated by a transmitted radar pulse. Since the complicated sea clutter signals depend on the complex wave motions on the sea surface, it is reasonable to study sea clutter from nonlinear dynamics, especially chaos, point of view, instead of simply based on random processes. In the past decade, Dr. Simon Haykin’...