Abstract Pituitary hormones are responsible for the regulation of growth, development, metabolism, reproduction, and homeostasis. Hypopituitarism is a condition that defined as partial or complete insufficiency anterior pituitary hormone secretion, rarely, posterior secretion. This can result from diseases gland hypothalamus. The annual incidence hypopituitarism has been estimated to be 4.2 per...

Sebum provides vital cutaneous functions including moisture retention and defense against the external environment, pathogens. Despite well-defined homeostatic of sebum in fortifying skin barrier, role microbiota-immune system axis regulation remains unclear. We have recently shown that keratinocyte-derived cytokine thymic stromal lymphopoietin (TSLP) promotes secretion through T cell stimulati...

Aims: Glucose evoked changes in profibrotic transforming growth factor-beta1 (TGFs1), increase connexin hemichannel mediated ATP release kidney proximal tubule cells. With linked to inflammation, we evaluated the efficacy of blocker Peptide 5 negating induced inflammatory cytokine secretion cells. Methods: Primary human tubular epithelial cells (hPTECs), and immortalised (HK2) were treated w...

Rheumatoid arthritis (RA) development is strongly associated with cigarette smoke exposure, which activates the aryl hydrocarbon receptor (AhR) as a trigger for Th17 inflammatory pathways. We previously demonstrated that exposure to hydroquinone (HQ), one of major compounds tar, aggravates symptomatology in rats. However, mechanisms related HQ-related RA still remain elusive. Cell viability, cy...

Jasminum amplexicaule Buch.-Ham. (Oleaceae) has been commonly used in the traditional medicine in dysentery, diarrhoea and bellyache in China. In the present work, the methanol extract of Jasminum amplexicaule (JME) was examined for pharmacology on human colonic epithelial cell line T84 by the short-circuit current technique. The results showed that pretreatment of T84 cells with JME produced a...