The reported interaction between the length polymorphism (5HTTLPR) in the serotonin transporter gene (SLC6A4) and stressful life events on depression has led to many attempts to replicate but with inconsistent results. This inconsistency may reflect, in part, small sample size and the unknown contribution of the long allele SNP, rs25531. Using a large twin sample of 3,243 individuals from 2,230...

The dopamine transporter mediates reuptake of dopamine from the synaptic cleft. The cellular mechanisms controlling dopamine transporter levels in striatal nerve terminals remain poorly understood. The dopamine transporters contain a C-terminal PDZ (PSD-95/Discs-large/ZO-1) domain-binding sequence believed to bind synaptic scaffolding proteins, but its functional significance is uncertain. Here...

Background Neuroticism is a major risk factor for affective disorders. This personality trait has been hypothesized to associate with synaptic availability of the serotonin transporter, which critically controls serotonergic tone in the brain. However, earlier studies linking neuroticism and serotonin transporter have failed to produce converging findings. Because sex affects both the serotoner...

BACKGROUND Several lines of evidence implicate abnormal serotonergic function in suicidal behavior and completed suicide, including low serotonin transporter binding in postmortem studies of completed suicide. We have also reported low in vivo serotonin transporter binding in major depressive disorder (MDD) during a major depressive episode using positron emission tomography (PET) with [(11)C]M...

Engineered peptide based biocompatible, siRNA transporter can transfect primary and TNBC cells with efficient long-term gene silencing. Nanocomplex silencing Notch1 exhibits synergistic interaction metformin amplifies anticancer therapy.

Abstract In traditional parcel delivery operations, customers determine locations and, hence, the performance of a transporter. We exploit this idea and show that can improve efficiency transporter by giving latter flexibility in choosing locations. Two possible policies to enable are presented evaluated. The first policy, conceptually similar roaming vehicle routing, is related presence altern...

Cancer cells are metabolically reprogrammed to support their high rates of proliferation, continuous growth, survival, invasion, metastasis, and resistance cancer treatments. Among changes in cell bioenergetics, the role glutamine metabolism has been receiving increasing attention. Increased glutaminolysis is associated with increased expression membrane transporters that mediate cellular uptak...

Software for two dimensional visualization of values that have been automatically measured with in place sensors is difficult to find. Usually these programs assume a regular area and a regular grid of measuring points. In practice, however, both the shape of the area and the position of the sensors are often irregular. This paper describes the program TDRFree, which visualizes the soil moistur...

OBJECTIVE To analyze glucose transporter 1 expression patterns in malignant tumors of various cell types and evaluate their diagnostic value by immunohistochemistry. INTRODUCTION Glucose is the major source of energy for cells, and glucose transporter 1 is the most common glucose transporter in humans. Glucose transporter 1 is aberrantly expressed in several tumor types. Studies have implicat...