Pharmaceutical compounds have been found in rivers and treated wastewaters. They often contaminate irrigation waters consequently accumulate edible vegetables, causing changes plants metabolism. The main objective of this work is to understand how lettuce cope with the contamination from three selected pharmaceuticals using a label free proteomic analysis. A hydroponic culture, grown for 36 day...

Exposure-response analysis of QT interval in clinical studies has been proposed as a thorough QT study alternative. Many exposure-response model structures have been proposed for cardiovascular (CV) safety markers, but few studies have compared models across multiple drugs. To recommend preferred drug-effect exposure-response models on vital signs and electrocardiogram (ECG) intervals, an indiv...

We performed artificial selection on the visual system in guppies (Poecilia reticulata), using the optomotor reaction threshold as the selection criterion. Two lines were selected for increased sensitivity to blue light, two were selected for increased sensitivity to red light, and two were unselected controls. There was significant response to selection in all four selected lines and significa...