Supramolecular substrate preorganization using DIMPHos ligands, which are bisphosphine ligands equipped with a carboxylate binding site, allows for control over the regioselectivity in hydroformylation reaction. In all reported examples, aldehyde product CO was inserted farthest from directing group, formed excess (for terminal alkenes linear aldehyde). We report here an in-depth DFT study to p...

Molecularly imprinting technology was applied for preparing selective sorbents benzophenone-4 (BP4), an organic UV filter used in sunscreens and cosmetics. Several imprinted polymers were prepared by bulk polymerization, using BP4 as template. Combination of stability (mechanical chemical), selectivity robustness the with properties resulted a successful process (imprinting factors range 1.05?2...

A simple and cost-effective optical sensing system based on quinizarin fluorescent dye (QZ) for the selective reversible of CH3COO? anions is reported. The anion binding affinity QZ towards different was monitored using electronic absorption fluorescence emission titration studies in DMSO. UV-visible spectrum showed a decrease intensity characteristic peaks at ? = 280, 323, 475 nm, while new pe...

Invading bacteria can be degraded by selective autophagy, known as xenophagy. Recent studies have shown that the recruitment of autophagy adaptor proteins such p62 to and its regulation activated TANK-binding kinase 1 (TBK1) are required overcome bacterial infection. However, detailed molecular mechanisms behind this not yet fully understood. Here, we show human guanylate-binding protein (GBP) ...

The adenosine A1 receptor (A1AR) is a G-protein-coupled (GPCR) that provides important therapeutic opportunities for number of conditions including congestive heart failure, tachycardia, and neuropathic pain. development A1AR-selective fluorescent ligands will enhance our understanding the subcellular mechanisms underlying A1AR pharmacology facilitating more efficacious selective therapies. Her...

In this paper we report the binding properties, by combined 1H NMR, optical absorption, and fluorescence studies, of a molecular tweezer composed two Zn(salen)-type Schiff-base units connected flexible spacer, towards series ditopic diamines having strong Lewis basicity, with different chain length rigidity. Except for 1,2-diaminoethane, in all other cases formation stable 1:1 acid-base adducts...

The pattern of expression of somatostatin receptor (SSTR) genes and gene products in AtT-20 cells was characterized in an attempt to explain the SST-28 binding selectivity that typifies these cells. AtT-20 cells expressed multiple SSTR mRNAs. Paradoxically, this included mRNA for three of the four SST-14 selective receptors: SSTR2 ( +), SSTR1 (+), SSTR4 (+). The SST-28 selective SSTR5 was expre...