John Chant toward the bud orient the nucleus and spindle for mitosis Figure 1 illustrates the key point that, once a yeast cell has initiated a bud early in the cell cycle, it has Cambridge, Massachusetts 02138 committed to its cleavage plane. The molecular manifestation of commitment is the formation of a ring of septin proteins (Cdc3p, Cdc10p, Cdc11p, and Cdc12p) be-For one cell to divide int...