نتایج جستجو برای: septo
تعداد نتایج: 499 فیلتر نتایج به سال:
The 5-HT6 receptor is a promising target for cognitive disorders, in particular for Alzheimer's disease (AD) and other CNS disorders. The high-affinity and selective 5-HT6 receptor antagonist idalopirdine (Lu AE58054) is currently in development for mild-moderate AD as adjunct therapy to acetylcholinesterase inhibitors (AChEIs). We studied the effects of idalopirdine alone and in combination wi...
Extensive evidence suggests that glucose has both positive and negative effects on memory and these effects likely involve an influence on the brain. For instance, direct infusions of glucose into the septum (MS) or hippocampus can enhance or impair memory. The present set of experiments attempted to determine the different conditions that dissociate the memory-enhancing and -impairing effects ...
Septo-optic dysplasia (De Morsier syndrome) is a developmental anomaly of mid-line brain structures and includes optic nerve hypoplasia, absence of the septum pellucidum and hypothalamo-pituitary abnormalities. We describe seven patients (four female, three male) who had at least two out of the three features necessary for the diagnosis of septo-optic dysplasia. Four patients had hypopituitaris...
BACKGROUND In patients with mitral valve regurgitation (MR), posterior mitral annuloplasty (PMA) was performed for mitral valve repair using a strip designed for placement in the posterior annulus, sparing the anterior annulus and anterior half of the commissures. METHODS Between September 2009 and October 2013, we performed PMA using a novel strip in 74 consecutive patients with MR greater t...
Abbreviations ChAT: Choline acetyl transferase dMRI: diffusion MRI FA: fractional anisotropy MCI: mild cognitive impairment MRI: magnetic resonance imaging p75 NTR : p75 neurotrophin receptor PB: phosphate buffer PBS: phosphate buffered saline ROI: region of interest SAP: saporin Manuscript Click here to view linked References 2 Abstract Loss of basal forebrain cholinergic neurons is an early a...
CONTEXT Fibroblast growth factor (FGF) 8 is important for GnRH neuronal development with human mutations resulting in Kallmann syndrome. Murine data suggest a role for Fgf8 in hypothalamo-pituitary development; however, its role in the etiology of wider hypothalamo-pituitary dysfunction in humans is unknown. OBJECTIVE The objective of this study was to screen for FGF8 mutations in patients wi...
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