We discuss the identification of features that are associated with an outcome in RNA-Sequencing (RNA-Seq) and other sequencing-based comparative genomic experiments. RNA-Seq data takes the form of counts, so models based on the normal distribution are generally unsuitable. The problem is especially challenging because different sequencing experiments may generate quite different total numbers o...

Massively parallel DNA sequencing is capable of sequencing tens of millions of DNA fragments at the same time. However, sequence bias in the initial cycles, which are used to determine the coordinates of individual clusters, causes a loss of fidelity in cluster identification on Illumina Genome Analysers. This can result in a significant reduction in the numbers of clusters that can be analysed...

We consider the problem of finding an optimal dynamic priority sequencing policy to maximize the mean throughput rate in a multistation, multiclass closed queueing network with general service time distributions and a general routing structure. Under balanced heavy loading conditions, this scheduling problem can be approximated by a control problem involving Brownian motion. Although a unique, ...

  The problem of lot sizing, sequencing and scheduling multiple products in flow line production systems has been studied by several authors. Almost all of the researches in this area assumed that setup times and costs are sequence –independent even though sequence dependent setups are common in practice. In this paper we present a new mixed integer non linear program (MINLP) and a heuristic me...

The first Waste Framework Directive issued by the European Union dates back to seventies but was drastically amended in last decade reduce environmental impacts of waste encouraging reuse, recycling and remanufacturing. Product recovery starts with disassembly which results high labor costs. Disassembly supports environmentally conscious choices like replacement defective parts extend life span...