Group sequential design has been widely applied in clinical trials in the past few decades. The sample size estimation is a vital concern of sponsors and investigators. Especially in the survival group sequential trials, it is a thorny question because of its ambiguous distributional form, censored data and different definition of information time. A practical and easy-to-use simulation-based m...

In order to improve post-licensure drug and vaccine safety surveillance, new systems are being developed that prospectively monitor observational health care data from large health plans. Continuous sequential testing has been proposed in this setting to facilitate rapid detection, but group sequential methods commonly used in randomized clinical trials (RCTs) have received less consideration. ...

In mining projects, all uncertainties associated with a project must be considered to determine the feasibility study. Grade uncertainty is one of the major components of technical uncertainty that affects the variability of the project. Geostatistical simulation, as a reliable approach, is the most widely used method to quantify risk analysis to overcome the drawbacks of the estimation methods...

The purpose of this research paper is to develop a framework to understand the consumer’s preference affecting variables and consumer’s perception choice in telecommunication service providers in India. The present study use a hybrid approach to access the relative efficiency based on fuzzy AHP and DEA model. The fuzzy AHP is used to determine weights of the consumer’s preference as criteria an...

Data parallel simulation involves simulating the behavior of a circuit over a number of test sequences simultaneously. Compared to other parallel simulation techniques, data parallel simulation requires less overhead for synchronization and communication, and it permits higher degrees of parallelism. We have implemented two data parallel versions of the switch-level simulator COSMOS. The rst ru...

Standard Clock (SC) simulation is an efficient form of discreteevent simulation that is applicable to systems with exponential interevent times. It achieves its efficiency by using a common event stream to construct, on sequential or parallel machines, many sample paths in parallel. However, on sequential machines the efficiency is limited by two factors: (1) A fundamental simulation method-rel...

Discusses the interaction between socio-economic systems and their natural environment, by examining the indicators of sustainable development. Areas covered by the operationalization of sustainable development indicators; Details on the global nature of environmental problems; Important strategy of the operationalization of sustainable development; Link between economic data and ecological ind...

Parallel and sequential implementations of the Multi-sensor Joint Probabilistic Data Association (MSJPDA) tracking algorithm are analyzed and compared. The sequential implementation is shown to be exponentially less computationally complex as the number of sensors increases. Simulation results suggest that the sequential method also yields better tracking performance on the average. This is pri...